(data stored in ACNUC7421 zone)

SWISSPROT: LRPC_BACSU

ID   LRPC_BACSU              Reviewed;         144 AA.
AC   P96582;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   11-DEC-2019, entry version 137.
DE   RecName: Full=HTH-type transcriptional regulator LrpC;
GN   Name=lrpC; Synonyms=ydaI; OrderedLocusNames=BSU04250;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   Kasahara Y., Nakai S., Lee S., Sadaie Y., Ogasawara N.;
RT   "A 148 kbp sequence of the region between 35 and 47 degree of the Bacillus
RT   subtilis genome.";
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   CHARACTERIZATION.
RX   PubMed=9341680; DOI=10.1007/s004380050546;
RA   Beloin C., Ayora S., Exley R., Hirschbein L., Ogasawara N., Kasahara Y.,
RA   Alonso J.C., Le Hegarat F.;
RT   "Characterization of an lrp-like (lrpC) gene from Bacillus subtilis.";
RL   Mol. Gen. Genet. 256:63-71(1997).
CC   -!- FUNCTION: Transcriptional regulator with a possible role in regulation
CC       of amino acid metabolism. Plays a role in the growth phase transition.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA19262.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; AB001488; BAA19262.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL009126; CAB12232.1; -; Genomic_DNA.
DR   PIR; F69653; F69653.
DR   RefSeq; NP_388306.1; NC_000964.3.
DR   RefSeq; WP_003246585.1; NZ_JNCM01000031.1.
DR   PDB; 2CFX; X-ray; 2.40 A; A/B/C/D/E/F/G/H=1-144.
DR   PDBsum; 2CFX; -.
DR   SMR; P96582; -.
DR   STRING; 224308.BSU04250; -.
DR   PaxDb; P96582; -.
DR   PRIDE; P96582; -.
DR   EnsemblBacteria; CAB12232; CAB12232; BSU04250.
DR   GeneID; 940147; -.
DR   KEGG; bsu:BSU04250; -.
DR   PATRIC; fig|224308.179.peg.451; -.
DR   eggNOG; COG1522; LUCA.
DR   HOGENOM; HOG000115327; -.
DR   InParanoid; P96582; -.
DR   KO; K03719; -.
DR   OMA; VAPCHRR; -.
DR   PhylomeDB; P96582; -.
DR   BioCyc; BSUB:BSU04250-MONOMER; -.
DR   EvolutionaryTrace; P96582; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000485; AsnC-type_HTH_dom.
DR   InterPro; IPR011008; Dimeric_a/b-barrel.
DR   InterPro; IPR019888; Tscrpt_reg_AsnC-typ.
DR   InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01037; AsnC_trans_reg; 1.
DR   PRINTS; PR00033; HTHASNC.
DR   SMART; SM00344; HTH_ASNC; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF54909; SSF54909; 1.
DR   PROSITE; PS50956; HTH_ASNC_2; 1.
PE   1: Evidence at protein level;
DR   PRODOM; P96582.
DR   SWISS-2DPAGE; P96582.
KW   3D-structure; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..144
FT                   /note="HTH-type transcriptional regulator LrpC"
FT                   /id="PRO_0000111740"
FT   DOMAIN          3..64
FT                   /note="HTH asnC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT   DNA_BIND        22..41
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT   HELIX           5..16
FT                   /evidence="ECO:0000244|PDB:2CFX"
FT   HELIX           22..29
FT                   /evidence="ECO:0000244|PDB:2CFX"
FT   HELIX           33..45
FT                   /evidence="ECO:0000244|PDB:2CFX"
FT   STRAND          48..56
FT                   /evidence="ECO:0000244|PDB:2CFX"
FT   HELIX           59..61
FT                   /evidence="ECO:0000244|PDB:2CFX"
FT   STRAND          65..73
FT                   /evidence="ECO:0000244|PDB:2CFX"
FT   HELIX           74..76
FT                   /evidence="ECO:0000244|PDB:2CFX"
FT   HELIX           78..86
FT                   /evidence="ECO:0000244|PDB:2CFX"
FT   STRAND          91..111
FT                   /evidence="ECO:0000244|PDB:2CFX"
FT   HELIX           112..122
FT                   /evidence="ECO:0000244|PDB:2CFX"
FT   TURN            123..125
FT                   /evidence="ECO:0000244|PDB:2CFX"
FT   STRAND          126..136
FT                   /evidence="ECO:0000244|PDB:2CFX"
SQ   SEQUENCE   144 AA;  16450 MW;  78852BE30103417F CRC64;
     MKLDQIDLNI IEELKKDSRL SMRELGRKIK LSPPSVTERV RQLESFGIIK QYTLEVDQKK
     LGLPVSCIVE ATVKNADYER FKSYIQTLPN IEFCYRIAGA ACYMLKINAE SLEAVEDFIN
     KTSPYAQTVT HVIFSEIDTK NGRG
//

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