(data stored in ACNUC7421 zone)

SWISSPROT: YDDH_BACSU

ID   YDDH_BACSU              Reviewed;         329 AA.
AC   P96645;
DT   16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   11-DEC-2019, entry version 100.
DE   RecName: Full=Probable endopeptidase YddH;
DE            EC=3.4.-.-;
DE   Flags: Precursor;
GN   Name=yddH; OrderedLocusNames=BSU04970;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   Kasahara Y., Nakai S., Lee S., Sadaie Y., Ogasawara N.;
RT   "A 148 kbp sequence of the region between 35 and 47 degree of the Bacillus
RT   subtilis genome.";
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- SIMILARITY: Belongs to the peptidase C40 family. {ECO:0000305}.
DR   EMBL; AB001488; BAA19334.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12304.1; -; Genomic_DNA.
DR   PIR; A69776; A69776.
DR   RefSeq; NP_388378.1; NC_000964.3.
DR   RefSeq; WP_009966633.1; NZ_JNCM01000031.1.
DR   SMR; P96645; -.
DR   STRING; 224308.BSU04970; -.
DR   CAZy; GH23; Glycoside Hydrolase Family 23.
DR   MEROPS; C40.007; -.
DR   PaxDb; P96645; -.
DR   PRIDE; P96645; -.
DR   DNASU; 938136; -.
DR   EnsemblBacteria; CAB12304; CAB12304; BSU04970.
DR   GeneID; 938136; -.
DR   KEGG; bsu:BSU04970; -.
DR   PATRIC; fig|224308.179.peg.528; -.
DR   eggNOG; ENOG4105K4H; Bacteria.
DR   eggNOG; COG0741; LUCA.
DR   eggNOG; COG0791; LUCA.
DR   HOGENOM; HOG000267549; -.
DR   OMA; EAVANNW; -.
DR   PhylomeDB; P96645; -.
DR   BioCyc; BSUB:BSU04970-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004175; F:endopeptidase activity; IDA:CACAO.
DR   GO; GO:0003796; F:lysozyme activity; IDA:CACAO.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   InterPro; IPR000064; NLP_P60_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   Pfam; PF00877; NLPC_P60; 1.
DR   SUPFAM; SSF53955; SSF53955; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
PE   3: Inferred from homology;
DR   PRODOM; P96645.
DR   SWISS-2DPAGE; P96645.
KW   Hydrolase; Protease; Reference proteome; Signal; Thiol protease.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..329
FT                   /note="Probable endopeptidase YddH"
FT                   /id="PRO_0000019764"
FT   ACT_SITE        237
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        290
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   329 AA;  36546 MW;  B1ADD487E5F5C38E CRC64;
     MISKKVVLPL VFSAPFIFFF VLCIVVVMTI SRENQVGDDF IGGGDGEYET VGIAPEVERF
     RAVFEKYARQ EGVFDQVNII MALTMQESGG RSLDIMQSSE SIGLPPNSIT DPERSIEVGI
     KHFKKVFKQA GGDVRLTLQA YNFGSGFIDY VKKNGGKYTK KLALDFSRLQ AFKMGWKSYG
     DPSYVDHVMR YVKGSDKNVK PVKGSMDFYE TVMKEALKYE GQPYAWGGSN PETGFDCSGL
     VQWSFAKAGI TLPRTAQEQH GATKKISEKE ATAGDLVFFG GTYEGKAITH VGIYVGNGRM
     FNSNDSGIQY SDLKSGYWRD HLVSFGRIK
//

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