(data stored in ACNUC7421 zone)

SWISSPROT: YDFH_BACSU

ID   YDFH_BACSU              Reviewed;         407 AA.
AC   P96685; Q797G6;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   11-DEC-2019, entry version 124.
DE   RecName: Full=Sensor histidine kinase YdfH;
DE            EC=2.7.13.3;
GN   Name=ydfH; OrderedLocusNames=BSU05410;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   Kasahara Y., Nakai S., Lee S., Sadaie Y., Ogasawara N.;
RT   "A 148 kbp sequence of the region between 35 and 47 degree of the Bacillus
RT   subtilis genome.";
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION.
RX   PubMed=11717295; DOI=10.1128/jb.183.24.7365-7370.2001;
RA   Kobayashi K., Ogura M., Yamaguchi H., Yoshida K., Ogasawara N., Tanaka T.,
RA   Fujita Y.;
RT   "Comprehensive DNA microarray analysis of Bacillus subtilis two-component
RT   regulatory systems.";
RL   J. Bacteriol. 183:7365-7370(2001).
RN   [4]
RP   FUNCTION.
RC   STRAIN=168;
RX   PubMed=15941986; DOI=10.1099/mic.0.27619-0;
RA   Serizawa M., Sekiguchi J.;
RT   "The Bacillus subtilis YdfHI two-component system regulates the
RT   transcription of ydfJ, a member of the RND superfamily.";
RL   Microbiology 151:1769-1778(2005).
CC   -!- FUNCTION: Member of the two-component regulatory system YdfH/YdfI. May
CC       activate YdfI by phosphorylation. {ECO:0000269|PubMed:11717295,
CC       ECO:0000269|PubMed:15941986}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
DR   EMBL; AB001488; BAA19375.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12348.1; -; Genomic_DNA.
DR   PIR; F69780; F69780.
DR   RefSeq; NP_388422.1; NC_000964.3.
DR   RefSeq; WP_010886422.1; NZ_JNCM01000031.1.
DR   SMR; P96685; -.
DR   STRING; 224308.BSU05410; -.
DR   PaxDb; P96685; -.
DR   PRIDE; P96685; -.
DR   EnsemblBacteria; CAB12348; CAB12348; BSU05410.
DR   GeneID; 938076; -.
DR   KEGG; bsu:BSU05410; -.
DR   PATRIC; fig|224308.179.peg.580; -.
DR   eggNOG; ENOG4105ENE; Bacteria.
DR   eggNOG; COG4585; LUCA.
DR   HOGENOM; HOG000084791; -.
DR   InParanoid; P96685; -.
DR   KO; K11623; -.
DR   OMA; QNERQRM; -.
DR   PhylomeDB; P96685; -.
DR   BioCyc; BSUB:BSU05410-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF07730; HisKA_3; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
PE   3: Inferred from homology;
DR   PRODOM; P96685.
DR   SWISS-2DPAGE; P96685.
KW   ATP-binding; Cell membrane; Kinase; Membrane; Nucleotide-binding;
KW   Phosphoprotein; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix; Two-component regulatory system.
FT   CHAIN           1..407
FT                   /note="Sensor histidine kinase YdfH"
FT                   /id="PRO_0000074917"
FT   TOPO_DOM        1..25
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        68..78
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..125
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        147..150
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..407
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          201..402
FT                   /note="Histidine kinase"
FT   MOD_RES         210
FT                   /note="Phosphohistidine; by autocatalysis"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   407 AA;  46506 MW;  17CEA71B400C9100 CRC64;
     MLIRNPFKDK YYSHDRRALN MLALRVPGLA FILMIYIASI VLQFVSGGWS ILLLYAFTIL
     IAIFALLHWH SYRWVKKRVI LYFAVQGLIT FALANLMTGF FILVIIGLYA FLIGQIIGMA
     DRRRTFLILY LLLLLVINSA YHLHKGEVLH FIVIAAPIMI VIITYAATFF AQVDEKIKAQ
     LTLERLELAH QQVEQLTLQN ERQRMARDLH DTLAQGLVSL NMQLDAIHVH LAKGNTERAK
     EIIQQSMKRV KSTIADARSA IDDLRSKSEE IGVLKERITS LMDHFIESTG MACLLDYRLH
     QVLDVRTAEN CYYIIGECMT NAAKHAEAKT IWISIWDDEK GRLHLTVKDN GKGFDVEKGK
     KKRGHYGLLG IQERVRAING QFNIKSTKLK GTQIEITVPI QGEMQDE
//

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