(data stored in SCRATCH zone)

SWISSPROT: V1AR_MOUSE

ID   V1AR_MOUSE              Reviewed;         423 AA.
AC   Q62463; Q62464; Q9QYH2;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   30-AUG-2017, entry version 143.
DE   RecName: Full=Vasopressin V1a receptor;
DE            Short=V1aR;
DE   AltName: Full=AVPR V1a;
DE   AltName: Full=Antidiuretic hormone receptor 1a;
DE   AltName: Full=Vascular/hepatic-type arginine vasopressin receptor;
GN   Name=Avpr1a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Onodera Y., Maekawa K., Arai Y.;
RL   Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129/SvJ;
RX   PubMed=10669045; DOI=10.1254/jjp.81.388;
RA   Kikuchi S., Tanoue A., Goda N., Matsuo N., Tsujimoto G.;
RT   "Structure and sequence of the mouse V1a and V1b vasopressin receptor
RT   genes.";
RL   Jpn. J. Pharmacol. 81:388-392(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   ROLE IN SOCIAL BEHAVIOR.
RX   PubMed=14647484; DOI=10.1038/sj.npp.1300360;
RA   Bielsky I.F., Hu S.B., Szegda K.L., Westphal H., Young L.J.;
RT   "Profound impairment in social recognition and reduction in anxiety-
RT   like behavior in vasopressin V1a receptor knockout mice.";
RL   Neuropsychopharmacology 29:483-493(2004).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA   Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of mouse liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC       receptor is mediated by G proteins which activate a phosphatidyl-
CC       inositol-calcium second messenger system. Involved in social
CC       memory formation. {ECO:0000269|PubMed:14647484}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- MISCELLANEOUS: Knockout mice display deficits in individual
CC       discrimination. Male mice lacking functional AVPR1A (V1aRKO)
CC       exhibit markedly reduced anxiety-like behavior and a profound
CC       impairment in social recognition. V1aRKO performed normally on
CC       spatial and non-social olfactory learning and memory tasks.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00521}.
DR   EMBL; D49729; BAA08566.1; -; mRNA.
DR   EMBL; D49730; BAA08567.1; -; mRNA.
DR   EMBL; AB030013; BAA89050.1; -; Genomic_DNA.
DR   EMBL; BC024149; AAH24149.1; -; mRNA.
DR   CCDS; CCDS24215.1; -.
DR   RefSeq; NP_058543.2; NM_016847.2.
DR   UniGene; Mm.4351; -.
DR   ProteinModelPortal; Q62463; -.
DR   STRING; 10090.ENSMUSP00000020323; -.
DR   BindingDB; Q62463; -.
DR   ChEMBL; CHEMBL3414410; -.
DR   iPTMnet; Q62463; -.
DR   PhosphoSitePlus; Q62463; -.
DR   PaxDb; Q62463; -.
DR   PRIDE; Q62463; -.
DR   Ensembl; ENSMUST00000020323; ENSMUSP00000020323; ENSMUSG00000020123.
DR   GeneID; 54140; -.
DR   KEGG; mmu:54140; -.
DR   UCSC; uc007hge.1; mouse.
DR   CTD; 552; -.
DR   MGI; MGI:1859216; Avpr1a.
DR   eggNOG; KOG3656; Eukaryota.
DR   eggNOG; ENOG410XRW9; LUCA.
DR   GeneTree; ENSGT00760000119156; -.
DR   HOGENOM; HOG000237331; -.
DR   HOVERGEN; HBG105710; -.
DR   InParanoid; Q62463; -.
DR   KO; K04226; -.
DR   OMA; VFAMFAS; -.
DR   OrthoDB; EOG091G0DB6; -.
DR   PhylomeDB; Q62463; -.
DR   TreeFam; TF106499; -.
DR   Reactome; R-MMU-388479; Vasopressin-like receptors.
DR   Reactome; R-MMU-416476; G alpha (q) signalling events.
DR   PRO; PR:Q62463; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   Bgee; ENSMUSG00000020123; -.
DR   CleanEx; MM_AVPR1A; -.
DR   ExpressionAtlas; Q62463; baseline and differential.
DR   Genevisible; Q62463; MM.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR   GO; GO:0017046; F:peptide hormone binding; IEA:Ensembl.
DR   GO; GO:0031894; F:V1A vasopressin receptor binding; IEA:Ensembl.
DR   GO; GO:0005000; F:vasopressin receptor activity; IBA:GO_Central.
DR   GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
DR   GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central.
DR   GO; GO:0042631; P:cellular response to water deprivation; IEA:Ensembl.
DR   GO; GO:0007625; P:grooming behavior; IEA:Ensembl.
DR   GO; GO:0002125; P:maternal aggressive behavior; IEA:Ensembl.
DR   GO; GO:0042711; P:maternal behavior; IBA:GO_Central.
DR   GO; GO:0014902; P:myotube differentiation; IEA:Ensembl.
DR   GO; GO:0007621; P:negative regulation of female receptivity; IEA:Ensembl.
DR   GO; GO:0051970; P:negative regulation of transmission of nerve impulse; IEA:Ensembl.
DR   GO; GO:0043084; P:penile erection; IEA:Ensembl.
DR   GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0032849; P:positive regulation of cellular pH reduction; IEA:Ensembl.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0014049; P:positive regulation of glutamate secretion; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0031394; P:positive regulation of prostaglandin biosynthetic process; IEA:Ensembl.
DR   GO; GO:0035815; P:positive regulation of renal sodium excretion; IEA:Ensembl.
DR   GO; GO:0003084; P:positive regulation of systemic arterial blood pressure; IEA:Ensembl.
DR   GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR   GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IGI:MGI.
DR   GO; GO:0051412; P:response to corticosterone; IEA:Ensembl.
DR   GO; GO:1901652; P:response to peptide; IBA:GO_Central.
DR   GO; GO:0035176; P:social behavior; IEA:Ensembl.
DR   GO; GO:0042713; P:sperm ejaculation; IEA:Ensembl.
DR   GO; GO:0021537; P:telencephalon development; IEA:Ensembl.
DR   CDD; cd15385; 7tmA_V1aR; 1.
DR   InterPro; IPR015076; DUF1856.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001817; Vasoprsn_rcpt.
DR   InterPro; IPR001224; Vprs_V1A_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   Pfam; PF08983; DUF1856; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00896; VASOPRESSINR.
DR   PRINTS; PR00752; VASOPRSNV1AR.
DR   SMART; SM01164; DUF1856; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q62463.
DR   SWISS-2DPAGE; Q62463.
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane;
KW   Palmitate; Phosphoprotein; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    423       Vasopressin V1a receptor.
FT                                /FTId=PRO_0000070200.
FT   TOPO_DOM      1     52       Extracellular. {ECO:0000255}.
FT   TRANSMEM     53     76       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     77     88       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     89    110       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM    111    125       Extracellular. {ECO:0000255}.
FT   TRANSMEM    126    147       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    148    168       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    169    190       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    191    220       Extracellular. {ECO:0000255}.
FT   TRANSMEM    221    241       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    242    298       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    299    318       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    319    336       Extracellular. {ECO:0000255}.
FT   TRANSMEM    337    356       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    357    423       Cytoplasmic. {ECO:0000255}.
FT   MOD_RES     409    409       Phosphoserine.
FT                                {ECO:0000244|PubMed:17242355,
FT                                ECO:0000244|PubMed:21183079}.
FT   LIPID       370    370       S-palmitoyl cysteine. {ECO:0000250}.
FT   LIPID       371    371       S-palmitoyl cysteine. {ECO:0000250}.
FT   CARBOHYD     27     27       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    198    198       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    124    205       {ECO:0000255|PROSITE-ProRule:PRU00521}.
FT   VARIANT      41     42       PP -> RR.
FT   VARIANT      55     55       V -> F.
SQ   SEQUENCE   423 AA;  47182 MW;  C75AFF1D0A082CC6 CRC64;
     MSFPRGSHDL PAGNSSPWWP LTTEGANSSR EAAGLGEGGS PPGDVRNEEL AKLEVTVLAV
     IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQLC WDITYRFRGP
     DWLCRVVKHL QVFAMFASSY MLVVMTADRY IAVCHPLKTL QQPARRSRLM IAASWGLSFV
     LSIPQYFIFS VIEFEVNNGT KAQDCWATFI PPWGTRAYVT WMTSGVFVVP VIILGTCYGF
     ICYHIWRNVR GKTASRQSKG GKGSGEAAGP FHKGLLVTPC VSSVKSISRA KIRTVKMTFV
     IVSAYILCWT PFFIVQMWSV WDTNFVWTDS ENPSTTITAL LASLNSCCNP WIYMFFSGHL
     LQDCVQSFPC CQSIAQKFAK DDSDSMSRRQ TSYSNNRSPT NSTGTWKDSP KSSKSIRFIP
     VST
//

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