(data stored in ACNUC7421 zone)

SWISSPROT: NHAA_ECO57

ID   NHAA_ECO57              Reviewed;         388 AA.
AC   Q8XA63; Q7AHU2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 95.
DE   RecName: Full=Na(+)/H(+) antiporter NhaA {ECO:0000255|HAMAP-Rule:MF_01844};
DE   AltName: Full=Sodium/proton antiporter NhaA {ECO:0000255|HAMAP-Rule:MF_01844};
GN   Name=nhaA {ECO:0000255|HAMAP-Rule:MF_01844};
GN   OrderedLocusNames=Z0018, ECs0017;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange
CC       for external protons. {ECO:0000255|HAMAP-Rule:MF_01844}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01844}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01844}.
CC   -!- SIMILARITY: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter
CC       family. {ECO:0000255|HAMAP-Rule:MF_01844}.
DR   EMBL; AE005174; AAG54317.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33440.1; -; Genomic_DNA.
DR   PIR; A85482; A85482.
DR   PIR; A99631; A99631.
DR   RefSeq; NP_308044.1; NC_002695.1.
DR   RefSeq; WP_000681368.1; NZ_MWVM01000003.1.
DR   ProteinModelPortal; Q8XA63; -.
DR   SMR; Q8XA63; -.
DR   STRING; 155864.Z0018; -.
DR   EnsemblBacteria; AAG54317; AAG54317; Z0018.
DR   EnsemblBacteria; BAB33440; BAB33440; BAB33440.
DR   GeneID; 913409; -.
DR   KEGG; ece:Z0018; -.
DR   KEGG; ecs:ECs0017; -.
DR   PATRIC; fig|386585.9.peg.113; -.
DR   eggNOG; ENOG4105DRC; Bacteria.
DR   eggNOG; COG3004; LUCA.
DR   HOGENOM; HOG000218489; -.
DR   KO; K03313; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1530.10; -; 1.
DR   HAMAP; MF_01844; NhaA; 1.
DR   InterPro; IPR023171; Na/H_antiporter_dom.
DR   InterPro; IPR004670; NhaA.
DR   PANTHER; PTHR30341:SF2; PTHR30341:SF2; 1.
DR   Pfam; PF06965; Na_H_antiport_1; 1.
DR   TIGRFAMs; TIGR00773; NhaA; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8XA63.
DR   SWISS-2DPAGE; Q8XA63.
KW   Antiport; Cell inner membrane; Cell membrane; Complete proteome;
KW   Ion transport; Membrane; Sodium; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN         1    388       Na(+)/H(+) antiporter NhaA.
FT                                /FTId=PRO_0000334286.
FT   TOPO_DOM      1     10       Cytoplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM     11     29       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TOPO_DOM     30     60       Periplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM     61     85       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TOPO_DOM     86     94       Cytoplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM     95    116       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TOPO_DOM    117    120       Periplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    121    143       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TOPO_DOM    144    149       Cytoplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    150    175       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TOPO_DOM    176    181       Periplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    182    200       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TOPO_DOM    201    204       Cytoplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    205    218       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TOPO_DOM    219    222       Periplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    223    236       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TOPO_DOM    237    246       Cytoplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    247    271       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TOPO_DOM    272    289       Periplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    290    311       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TOPO_DOM    312    326       Cytoplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    327    350       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TOPO_DOM    351    356       Periplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TRANSMEM    357    387       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
FT   TOPO_DOM    388    388       Cytoplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_01844}.
SQ   SEQUENCE   388 AA;  41374 MW;  0FBD884FD9249354 CRC64;
     MKHLHRFFSS DASGGIILII AAILAMMMAN SGATSGWYHD FLETPVQLRV GSLEINKNML
     LWINDALMAV FFLLVGLEVK RELMQGSLAS LRQAAFPVIA AIGGMIVPAL LYLAFNYADP
     ITREGWAIPA ATDIAFALGV LALLGSRVPL ALKIFLMALA IIDDLGAIII IALFYTNDLS
     MASLGVAAVA IAVLAVLNLC GVRRTGVYIL VGVVLWTAVL KSGVHATLAG VIVGFFIPLK
     EKHGRSPAKR LEHVLHPWVA YLILPLFAFA NAGVSLQGVT LDGLTSILPL GIIAGLLIGK
     PLGISLFCWL ALRLKLAHLP EGTTYQQIMA VGILCGIGFT MSIFIASLAF GSVDPELINW
     AKLGILVGSI SSAVIGYSWL RVRLRPSV
//

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