(data stored in ACNUC7421 zone)

SWISSPROT: CAIT_ECO57

ID   CAIT_ECO57              Reviewed;         504 AA.
AC   Q8XA30;
DT   22-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 95.
DE   RecName: Full=L-carnitine/gamma-butyrobetaine antiporter {ECO:0000255|HAMAP-Rule:MF_01049};
GN   Name=caiT {ECO:0000255|HAMAP-Rule:MF_01049};
GN   OrderedLocusNames=Z0046, ECs0043;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Catalyzes the exchange of L-carnitine for gamma-
CC       butyrobetaine and related betaines. {ECO:0000255|HAMAP-
CC       Rule:MF_01049}.
CC   -!- PATHWAY: Amine and polyamine metabolism; carnitine metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_01049}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01049}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01049}.
CC   -!- SIMILARITY: Belongs to the BCCT transporter (TC 2.A.15) family.
CC       CaiT subfamily. {ECO:0000255|HAMAP-Rule:MF_01049}.
DR   EMBL; AE005174; AAG54343.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33466.1; -; Genomic_DNA.
DR   PIR; C85485; C85485.
DR   PIR; C90634; C90634.
DR   RefSeq; NP_308070.1; NC_002695.1.
DR   RefSeq; WP_000787124.1; NZ_MWVM01000003.1.
DR   ProteinModelPortal; Q8XA30; -.
DR   SMR; Q8XA30; -.
DR   STRING; 155864.Z0046; -.
DR   EnsemblBacteria; AAG54343; AAG54343; Z0046.
DR   EnsemblBacteria; BAB33466; BAB33466; BAB33466.
DR   GeneID; 913440; -.
DR   KEGG; ece:Z0046; -.
DR   KEGG; ecs:ECs0043; -.
DR   PATRIC; fig|386585.9.peg.140; -.
DR   eggNOG; ENOG4105C94; Bacteria.
DR   eggNOG; COG1292; LUCA.
DR   HOGENOM; HOG000053240; -.
DR   KO; K05245; -.
DR   UniPathway; UPA00117; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044667; F:(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity; IEA:InterPro.
DR   GO; GO:1900751; P:4-(trimethylammonio)butanoate transport; IEA:InterPro.
DR   GO; GO:0009437; P:carnitine metabolic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_01049; CaiT; 1.
DR   InterPro; IPR018093; BCCT_CS.
DR   InterPro; IPR000060; BCCT_transptr.
DR   InterPro; IPR023449; BCCT_transptr_CaiT.
DR   PANTHER; PTHR30047; PTHR30047; 1.
DR   PANTHER; PTHR30047:SF9; PTHR30047:SF9; 1.
DR   Pfam; PF02028; BCCT; 1.
DR   TIGRFAMs; TIGR00842; bcct; 1.
DR   PROSITE; PS01303; BCCT; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8XA30.
DR   SWISS-2DPAGE; Q8XA30.
KW   Antiport; Cell inner membrane; Cell membrane; Complete proteome;
KW   Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    504       L-carnitine/gamma-butyrobetaine
FT                                antiporter.
FT                                /FTId=PRO_0000201488.
FT   TRANSMEM     13     30       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM     50     72       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM     92    114       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM    141    163       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM    195    214       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM    229    251       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM    264    286       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM    312    334       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM    347    366       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM    410    432       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM    445    467       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM    472    494       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
SQ   SEQUENCE   504 AA;  56581 MW;  19F0FBB6882E0941 CRC64;
     MKNEKRKTGI EPKVFFPPLI IVGILCWLTV RDLDAANVVI NAVFSYVTNV WGWAFEWYMV
     VMLFGWFWLV FGPYAKKRLG NEPPEFSTAS WIFMMFASCT SAAVLFWGSI EIYYYISTPP
     FGLEPNSTGA KELGLAYSLF LWGPLPWATY SFLSVAFAYF FFVRKMEVIR PSSTLVPLVG
     EKHAKGLFGT IVDNFYLVAL IFAMGTSLGL ATPLVTECMQ WLFGIPHTLQ LDAIIITCWI
     ILNAICVACG LQKGVRIASD VRSYLSFLML GWVFIVSGAS FIMNYFTDSV GMLLMYLPRM
     LFYTDPIAKG GFPQGWTVFY WAWWVIYAIQ MSIFLARISR GRTVRELCFG MVMGLTASTW
     ILWTVLGSNT LLLIDKNIIN IPNLIEQYGV ARAIIETWAA LPLSTATMWG FFILCFIATV
     TLVNACSYTL AMSTCREVRD GEEPPLLVRI GWSILVGIIG IVLLALGGLK PIQTAIIAGG
     CPLFFVNIMV TLSFIKDAKQ NWKD
//

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