(data stored in ACNUC7421 zone)

SWISSPROT: LPTD_ECO57

ID   LPTD_ECO57              Reviewed;         784 AA.
AC   Q8XA13;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 98.
DE   RecName: Full=LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule:MF_01411};
DE   Flags: Precursor;
GN   Name=lptD {ECO:0000255|HAMAP-Rule:MF_01411}; Synonyms=imp, ostA;
GN   OrderedLocusNames=Z0063, ECs0059;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Together with LptE, is involved in the assembly of
CC       lipopolysaccharide (LPS) at the surface of the outer membrane.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBUNIT: Component of the lipopolysaccharide transport and
CC       assembly complex. Interacts with LptE and LptA.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
CC   -!- PTM: Contains two intramolecular disulfide bonds.
CC       {ECO:0000255|HAMAP-Rule:MF_01411}.
CC   -!- SIMILARITY: Belongs to the LptD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01411}.
DR   EMBL; AE005174; AAG54359.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33482.1; -; Genomic_DNA.
DR   PIR; C85487; C85487.
DR   PIR; C90636; C90636.
DR   RefSeq; NP_308086.1; NC_002695.1.
DR   RefSeq; WP_000746183.1; NZ_MWVM01000003.1.
DR   ProteinModelPortal; Q8XA13; -.
DR   SMR; Q8XA13; -.
DR   STRING; 155864.Z0063; -.
DR   PRIDE; Q8XA13; -.
DR   EnsemblBacteria; AAG54359; AAG54359; Z0063.
DR   EnsemblBacteria; BAB33482; BAB33482; BAB33482.
DR   GeneID; 913459; -.
DR   KEGG; ece:Z0063; -.
DR   KEGG; ecs:ECs0059; -.
DR   PATRIC; fig|386585.9.peg.158; -.
DR   eggNOG; ENOG4105E7H; Bacteria.
DR   eggNOG; COG1452; LUCA.
DR   HOGENOM; HOG000218450; -.
DR   KO; K04744; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:InterPro.
DR   GO; GO:0015920; P:lipopolysaccharide transport; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IEA:InterPro.
DR   HAMAP; MF_01411; LPS_assembly_LptD; 1.
DR   InterPro; IPR020889; LipoPS_assembly_LptD.
DR   InterPro; IPR005653; OstA-like_N.
DR   InterPro; IPR007543; OstA_C.
DR   Pfam; PF03968; OstA; 1.
DR   Pfam; PF04453; OstA_C; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8XA13.
DR   SWISS-2DPAGE; Q8XA13.
KW   Cell outer membrane; Complete proteome; Disulfide bond; Membrane;
KW   Signal.
FT   SIGNAL        1     24       {ECO:0000255|HAMAP-Rule:MF_01411}.
FT   CHAIN        25    784       LPS-assembly protein LptD.
FT                                /FTId=PRO_0000020278.
FT   DISULFID     31    724       {ECO:0000255|HAMAP-Rule:MF_01411}.
FT   DISULFID    173    725       {ECO:0000255|HAMAP-Rule:MF_01411}.
SQ   SEQUENCE   784 AA;  89660 MW;  C8BD44858033F93F CRC64;
     MKKRIPTLLA TMIATALYSQ QGLAADLASQ CMLGVPSYDR PLVQGDTNDL PVTINANHAK
     GDYPDDAVFT GSVDIMQGNS RLQADEVQLH QKEAPGQPEP VRTVDALGNV HYDDNQVILK
     GPKGWANLNT KDTNVWEGDY QMVGRQGRGK ADLMKQRGEN RYTILDNGSF TSCLPGSDTW
     SVVGSEIIHD REEQVAEIWN ARFKVGPVSI FYSPYLQLPV GDKRRSGFLI PNAKYTTTNY
     FEFYLPYYWN IAPNMDATIT PHYMHRRGNI MWENEFRYLS QAGAGLMELD YLPSDKVYED
     EHPNDDSSRR WLFYWNHSGV MDQVWRFNVD YTKVSDPSYF NDFDNKYGSS TDGYATQKFS
     VGYAVQNFNA TVSTKQFQVF SEQNTSSYSA EPQLDVNYYQ NDVGPFDTRI YGQAVHFVNT
     RDDMPEATRV HLEPTINLPL SNNWGSINTE AKLLATHYQQ TNLDWYNSRN TTKLDESVNR
     VMPQFKVDGK MVFERDMEML APGYTQTLEP RAQYLYVPYR DQSDIYNYDS SLLQSDYSGL
     FRDRTYGGLD RIASANQVTT GVTSRIYDDA AVERFNISVG QIYYFTESRT GDDNITWEND
     DKTGSLVWAG DTYWRISERW GLRGGIQYDT RLDNVATSNS SIEYRRDEDR LVQLNYRYAS
     PEYIQATLPK YYSTAEQYKN GISQVGAVAS WPIADRWSIV GAYYYDTNAN KQADSMLGVQ
     YSSCCYAIRV GYERKLNGWD NDKQHAVYDN AIGFNIELRG LSSNYGLGTQ EMLRSNILPY
     QNTL
//

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