(data stored in ACNUC7421 zone)

SWISSPROT: ARAC_ECO57

ID   ARAC_ECO57              Reviewed;         292 AA.
AC   P0A9E1; P03021; Q47056;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   30-AUG-2017, entry version 90.
DE   RecName: Full=Arabinose operon regulatory protein;
GN   Name=araC; OrderedLocusNames=Z0073, ECs0068;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: This protein controls the expression of at least six
CC       genes that are involved in the transport and catabolism of L-
CC       arabinose. It regulates initiation of transcription of the araBAD
CC       operon and it also controls its own synthesis. The L-arabinose
CC       operon displays both positive and negative regulation through AraC
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
DR   EMBL; AE005174; AAG54368.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33491.1; -; Genomic_DNA.
DR   PIR; D85488; D85488.
DR   PIR; D90637; D90637.
DR   RefSeq; NP_308095.1; NC_002695.1.
DR   RefSeq; WP_001300811.1; NZ_MWVM01000003.1.
DR   ProteinModelPortal; P0A9E1; -.
DR   SMR; P0A9E1; -.
DR   STRING; 155864.Z0073; -.
DR   EnsemblBacteria; AAG54368; AAG54368; Z0073.
DR   EnsemblBacteria; BAB33491; BAB33491; BAB33491.
DR   GeneID; 913473; -.
DR   KEGG; ece:Z0073; -.
DR   KEGG; ecs:ECs0068; -.
DR   PATRIC; fig|386585.9.peg.168; -.
DR   eggNOG; ENOG41063TF; Bacteria.
DR   eggNOG; ENOG4111G16; LUCA.
DR   HOGENOM; HOG000276603; -.
DR   KO; K02099; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0019568; P:arabinose catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   InterPro; IPR003313; AraC-bd.
DR   InterPro; IPR009057; Homeobox-like.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF02311; AraC_binding; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0A9E1.
DR   SWISS-2DPAGE; P0A9E1.
KW   Activator; Arabinose catabolism; Carbohydrate metabolism;
KW   Complete proteome; Cytoplasm; DNA-binding; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    292       Arabinose operon regulatory protein.
FT                                /FTId=PRO_0000194500.
FT   DNA_BIND    197    216       H-T-H motif. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00593}.
FT   REGION        1      ?       Dimerization. {ECO:0000250}.
SQ   SEQUENCE   292 AA;  33384 MW;  C5A737E285A4ECC6 CRC64;
     MAEAQNDPLL PGYSFNAHLV AGLTPIEANG YLDFFIDRPL GMKGYILNLT IRGQGVVKNQ
     GREFVCRPGD ILLFPPGEIH HYGRHPEARE WYHQWVYFRP RAYWHEWLNW PSIFANTGFF
     RPDEAHQPHF SDLFGQIINA GQGEGRYSEL LAINLLEQLL LRRMEAINES LHPPMDNRVR
     EACQYISDHL ADSNFDIASV AQHVCLSPSR LSHLFRQQLG ISVLSWREDQ RISQAKLLLS
     TTRMPIATVG RNVGFDDQLY FSRVFKKCTG ASPSEFRAGC EEKVNDVAVK LS
//

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