(data stored in ACNUC7421 zone)

SWISSPROT: SGRR_ECO57

ID   SGRR_ECO57              Reviewed;         552 AA.
AC   Q8XA02; Q7AHR6;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 91.
DE   RecName: Full=HTH-type transcriptional regulator SgrR {ECO:0000255|HAMAP-Rule:MF_01449};
GN   Name=sgrR {ECO:0000255|HAMAP-Rule:MF_01449};
GN   OrderedLocusNames=Z0079, ECs0074;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Activates the small RNA gene sgrS under glucose-
CC       phosphate stress conditions as well as yfdZ. Represses its own
CC       transcription under both stress and non-stress conditions. Might
CC       act as a sensor of the intracellular accumulation of
CC       phosphoglucose by binding these molecules in its C-terminal
CC       solute-binding domain. {ECO:0000255|HAMAP-Rule:MF_01449}.
DR   EMBL; AE005174; AAG54374.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33497.1; -; Genomic_DNA.
DR   PIR; B85489; B85489.
DR   PIR; B90638; B90638.
DR   RefSeq; NP_308101.1; NC_002695.1.
DR   RefSeq; WP_001138626.1; NZ_MWVM01000003.1.
DR   ProteinModelPortal; Q8XA02; -.
DR   STRING; 155864.Z0079; -.
DR   EnsemblBacteria; AAG54374; AAG54374; Z0079.
DR   EnsemblBacteria; BAB33497; BAB33497; BAB33497.
DR   GeneID; 913502; -.
DR   KEGG; ece:Z0079; -.
DR   KEGG; ecs:ECs0074; -.
DR   PATRIC; fig|386585.9.peg.174; -.
DR   eggNOG; ENOG4105KNR; Bacteria.
DR   eggNOG; COG4533; LUCA.
DR   HOGENOM; HOG000271136; -.
DR   KO; K11925; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01449; HTH_type_SgrR; 1.
DR   InterPro; IPR000914; SBP_5_dom.
DR   InterPro; IPR025370; SgrR_HTH_N.
DR   InterPro; IPR023767; Tscrpt_reg_SgrR.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF00496; SBP_bac_5; 1.
DR   Pfam; PF12793; SgrR_N; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8XA02.
DR   SWISS-2DPAGE; Q8XA02.
KW   Activator; Complete proteome; DNA-binding; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    552       HTH-type transcriptional regulator SgrR.
FT                                /FTId=PRO_0000309242.
FT   DOMAIN        1    116       HTH marR-type. {ECO:0000255|HAMAP-
FT                                Rule:MF_01449}.
FT   DNA_BIND     26     49       H-T-H motif. {ECO:0000255|HAMAP-
FT                                Rule:MF_01449}.
FT   REGION      163    492       Solute-binding. {ECO:0000255|HAMAP-
FT                                Rule:MF_01449}.
SQ   SEQUENCE   552 AA;  64120 MW;  E4199F7F23E8C23E CRC64;
     MPSARLQQQF IRLWQCCEGK SQDTTLNELA ALLSCSRRHM RTLLNTMQDR GWLTWEAEVG
     RGKRSRLTFL YTGLALQQQR AEDLLEQDRI DQLVQLVGDK ATVRQMLVSH LGRSFRQGRH
     ILRVLYYRPL RNLLPGSALR RSETHIARQI FSSLTRINEE NGELEADIAH HWQQISPLHW
     RFFLRPGVHF HHGRELEMDD VIASLKRINT LPLYSHIADI VSPTPWTLDI HLTQPDRWLP
     LLLGQVPAMI LPREWETLSN FASHPIGTGP YAVIRNSTNQ LKIQAFDDFF GYRALIDEVN
     VWVLPEIADE PAGGLMLKGP QGEEKEIESR LEEGCYYLLF DSRTHRGANQ QVRDWVSYVL
     SPTNLVYFAE EQYQQLWFPA YGLLPRWHHA RTITSEKPAG LESLTLTFYQ DHSEHRVIAG
     IMQQILASHQ VTLEIKEISY DQWHEGEIES DIWLNSANFT LPLDFSLFAH LCEVPLLQHC
     IPIDWQVDAA RWRNGEMNLA NWCQQLVASK AMVPLIHHWL IIQGQRSMRG LRMNTLGWFD
     FKSAWFAPPD PE
//

If you have problems or comments...

PBIL Back to PBIL home page