(data stored in ACNUC7421 zone)

SWISSPROT: SECM_ECO57

ID   SECM_ECO57              Reviewed;         170 AA.
AC   P62397; P58327;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   05-JUL-2017, entry version 68.
DE   RecName: Full=Secretion monitor {ECO:0000255|HAMAP-Rule:MF_01332};
DE   Flags: Precursor;
GN   Name=secM {ECO:0000255|HAMAP-Rule:MF_01332};
GN   OrderedLocusNames=Z0107, ECs0101;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Regulates secA expression by translational coupling of
CC       the secM secA operon. Translational pausing at a specific Pro
CC       residue 5 residues before the end of the protein may allow
CC       disruption of a mRNA repressor helix that normally suppresses secA
CC       translation initiation. {ECO:0000255|HAMAP-Rule:MF_01332}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-
CC       Rule:MF_01332}. Periplasm {ECO:0000255|HAMAP-Rule:MF_01332}.
CC       Note=The active form is cytosolic, while the periplasmic form is
CC       rapidly degraded, mainly by the tail-specific protease.
CC       {ECO:0000255|HAMAP-Rule:MF_01332}.
CC   -!- SIMILARITY: Belongs to the SecM family. {ECO:0000255|HAMAP-
CC       Rule:MF_01332}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG54401.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB33524.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; AE005174; AAG54401.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB33524.1; ALT_INIT; Genomic_DNA.
DR   PIR; E85492; E85492.
DR   PIR; E90641; E90641.
DR   RefSeq; NP_308128.2; NC_002695.1.
DR   RefSeq; WP_000014320.1; NZ_MWVM01000012.1.
DR   STRING; 155864.Z0107; -.
DR   EnsemblBacteria; AAG54401; AAG54401; Z0107.
DR   EnsemblBacteria; BAB33524; BAB33524; BAB33524.
DR   GeneID; 913588; -.
DR   KEGG; ece:Z0107; -.
DR   KEGG; ecs:ECs0101; -.
DR   PATRIC; fig|386585.9.peg.201; -.
DR   eggNOG; ENOG4108SR7; Bacteria.
DR   eggNOG; ENOG4111GJA; LUCA.
DR   HOGENOM; HOG000267813; -.
DR   KO; K13301; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR   HAMAP; MF_01332; SecM; 1.
DR   InterPro; IPR009502; SecM.
DR   Pfam; PF06558; SecM; 1.
DR   PIRSF; PIRSF004572; SecM; 1.
DR   ProDom; PD089227; SecM; 1.
PE   3: Inferred from homology;
DR   PRODOM; P62397.
DR   SWISS-2DPAGE; P62397.
KW   Complete proteome; Cytoplasm; Periplasm; Signal.
FT   SIGNAL        1     37       {ECO:0000255|HAMAP-Rule:MF_01332}.
FT   CHAIN        38    170       Secretion monitor.
FT                                /FTId=PRO_0000031989.
SQ   SEQUENCE   170 AA;  18866 MW;  5B4B3001056CAD22 CRC64;
     MSGILTRWRQ FGKRYFWPHL LLGMVAASLG LPALSNAAEP NAPAKATTRN HEPSAKVNFG
     QLALLEANTR RPNSNYSVDY WHQHAIRTVI RHLSFAMAPQ TLPVAEESLP LQAQHLALLD
     TLSALLTQEG TPSEKGYRID YAHFTPQAKF STPVWISQAQ GIRAGPQRLS
//

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