(data stored in ACNUC7421 zone)

SWISSPROT: AROP_ECO57

ID   AROP_ECO57              Reviewed;         457 AA.
AC   Q8X968;
DT   20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 90.
DE   RecName: Full=Aromatic amino acid transport protein AroP;
DE   AltName: Full=General aromatic amino acid permease;
GN   Name=aroP; OrderedLocusNames=Z0122, ECs0116;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Permease that is involved in the transport across the
CC       cytoplasmic membrane of the aromatic amino acids (phenylalanine,
CC       tyrosine, and tryptophan). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
CC       {ECO:0000305}.
DR   EMBL; AE005174; AAG54416.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33539.1; -; Genomic_DNA.
DR   PIR; D85494; D85494.
DR   PIR; D90643; D90643.
DR   RefSeq; NP_308143.1; NC_002695.1.
DR   RefSeq; WP_010904500.1; NZ_MWVM01000012.1.
DR   ProteinModelPortal; Q8X968; -.
DR   STRING; 155864.Z0122; -.
DR   EnsemblBacteria; AAG54416; AAG54416; Z0122.
DR   EnsemblBacteria; BAB33539; BAB33539; BAB33539.
DR   GeneID; 913640; -.
DR   KEGG; ece:Z0122; -.
DR   KEGG; ecs:ECs0116; -.
DR   PATRIC; fig|386585.9.peg.214; -.
DR   eggNOG; ENOG4105C85; Bacteria.
DR   eggNOG; COG1113; LUCA.
DR   HOGENOM; HOG000261849; -.
DR   KO; K11734; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015171; F:amino acid transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   InterPro; IPR004840; Amoino_acid_permease_CS.
DR   Pfam; PF00324; AA_permease; 1.
DR   PIRSF; PIRSF006060; AA_transporter; 1.
DR   PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8X968.
DR   SWISS-2DPAGE; Q8X968.
KW   Amino-acid transport; Cell inner membrane; Cell membrane;
KW   Complete proteome; Membrane; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN         1    457       Aromatic amino acid transport protein
FT                                AroP.
FT                                /FTId=PRO_0000054195.
FT   TOPO_DOM      1     19       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     20     40       Helical. {ECO:0000255}.
FT   TOPO_DOM     41     42       Periplasmic. {ECO:0000255}.
FT   TRANSMEM     43     63       Helical. {ECO:0000255}.
FT   TOPO_DOM     64     86       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     87    107       Helical. {ECO:0000255}.
FT   TOPO_DOM    108    117       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    118    138       Helical. {ECO:0000255}.
FT   TOPO_DOM    139    155       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    156    176       Helical. {ECO:0000255}.
FT   TOPO_DOM    177    201       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    202    222       Helical. {ECO:0000255}.
FT   TOPO_DOM    223    240       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    241    261       Helical. {ECO:0000255}.
FT   TOPO_DOM    262    271       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    272    292       Helical. {ECO:0000255}.
FT   TOPO_DOM    293    333       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    334    354       Helical. {ECO:0000255}.
FT   TOPO_DOM    355    358       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    359    379       Helical. {ECO:0000255}.
FT   TOPO_DOM    380    407       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    408    428       Helical. {ECO:0000255}.
FT   TOPO_DOM    429    429       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    430    450       Helical. {ECO:0000255}.
FT   TOPO_DOM    451    457       Cytoplasmic. {ECO:0000255}.
SQ   SEQUENCE   457 AA;  49663 MW;  20A0C2A5075BC7A7 CRC64;
     MMEGQQHGEQ LKRGLKNRHI QLIALGGAIG TGLFLGSASV IQSAGPGIIL GYAIAGFIAF
     LIMRQLGEMV VEEPVAGSFS HFAYKYWGSF AGFASGWNYW VLYVLVAMAE LTAVGKYIQF
     WYPEIPTWVS AAVFFVVINA INLTNVTVFG EMEFWFAIIK VIAVVAMIIF GGWLLFSGNG
     GPQASVSNLW DQGGFLPHGF TGLVMMMAII MFSFGGLELV GITAAEADNP EQSIPKATNQ
     VIYRILIFYI GSLAVLLSLM PWTRVTADTS PFVLIFHELG DTFVANALNI VVLTAALSVY
     NSCVYCNSRM LFGLAQQGNA PKALASVDKR GVPVNTILVS ALVTALCVLI NYLAPESAFG
     LLMALVVSAL VINWAMISLA HMKFRRAKQE QGVVTRFPAL LYPLGNWICL LFMAVVLVIM
     LMTPGMAISV YLIPVWLVVL GIGYLFKEKT AKAVKAH
//

If you have problems or comments...

PBIL Back to PBIL home page