(data stored in ACNUC7421 zone)

SWISSPROT: PDHR_ECO57

ID   PDHR_ECO57              Reviewed;         254 AA.
AC   P0ACM1; P06957; Q53381;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   05-JUL-2017, entry version 76.
DE   RecName: Full=Pyruvate dehydrogenase complex repressor;
GN   Name=pdhR; OrderedLocusNames=Z0123, ECs0117;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Transcriptional repressor for the pyruvate dehydrogenase
CC       complex genes aceEF and lpd. {ECO:0000250}.
DR   EMBL; AE005174; AAG54417.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33540.1; -; Genomic_DNA.
DR   PIR; E85494; E85494.
DR   PIR; E90643; E90643.
DR   RefSeq; NP_308144.1; NC_002695.1.
DR   RefSeq; WP_000331776.1; NZ_MWVM01000012.1.
DR   ProteinModelPortal; P0ACM1; -.
DR   SMR; P0ACM1; -.
DR   STRING; 155864.Z0123; -.
DR   EnsemblBacteria; AAG54417; AAG54417; Z0123.
DR   EnsemblBacteria; BAB33540; BAB33540; BAB33540.
DR   GeneID; 913643; -.
DR   KEGG; ece:Z0123; -.
DR   KEGG; ecs:ECs0117; -.
DR   PATRIC; fig|386585.9.peg.215; -.
DR   eggNOG; ENOG41073TP; Bacteria.
DR   eggNOG; COG2186; LUCA.
DR   HOGENOM; HOG000273991; -.
DR   KO; K05799; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0ACM1.
DR   SWISS-2DPAGE; P0ACM1.
KW   Complete proteome; DNA-binding; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    254       Pyruvate dehydrogenase complex repressor.
FT                                /FTId=PRO_0000050663.
FT   DOMAIN        9     77       HTH gntR-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00307}.
FT   DNA_BIND     37     56       H-T-H motif. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00307}.
SQ   SEQUENCE   254 AA;  29425 MW;  AF20245D3D3F751D CRC64;
     MAYSKIRQPK LSDVIEQQLE FLILEGTLRP GEKLPPEREL AKQFDVSRPS LREAIQRLEA
     KGLLLRRQGG GTFVQSSLWQ SFSDPLVELL SDHPESQYDL LETRHALEGI AAYYAALRST
     DEDKERIREL HHAIELAQQS GDLDAESNAV LQYQIAVTEA AHNVVLLHLL RCMEPMLAQN
     VRQNFELLYS RREMLPLVSS HRTRIFEAIM AGKPEEAREA SHRHLAFIEE ILLDRSREES
     RRERSLRRLE QRKN
//

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