(data stored in ACNUC7421 zone)

SWISSPROT: DKSA_ECO57

ID   DKSA_ECO57              Reviewed;         151 AA.
AC   P0ABS3; P18274;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   08-MAY-2019, entry version 83.
DE   RecName: Full=RNA polymerase-binding transcription factor DksA {ECO:0000255|HAMAP-Rule:MF_00926};
GN   Name=dksA {ECO:0000255|HAMAP-Rule:MF_00926};
GN   OrderedLocusNames=Z0156, ECs0149;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Transcription factor that acts by binding directly to
CC       the RNA polymerase (RNAP). Required for negative regulation of
CC       rRNA expression and positive regulation of several amino acid
CC       biosynthesis promoters. Also required for regulation of fis
CC       expression. {ECO:0000255|HAMAP-Rule:MF_00926}.
CC   -!- SUBUNIT: Interacts directly with the RNA polymerase.
CC       {ECO:0000255|HAMAP-Rule:MF_00926}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00926}.
CC   -!- SIMILARITY: Belongs to the DksA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00926}.
DR   EMBL; AE005174; AAG54449.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33572.1; -; Genomic_DNA.
DR   PIR; E85498; E85498.
DR   PIR; E90647; E90647.
DR   RefSeq; NP_308176.1; NC_002695.1.
DR   RefSeq; WP_001155227.1; NZ_SDVX01000001.1.
DR   SMR; P0ABS3; -.
DR   STRING; 155864.EDL933_0149; -.
DR   PRIDE; P0ABS3; -.
DR   EnsemblBacteria; AAG54449; AAG54449; Z0156.
DR   EnsemblBacteria; BAB33572; BAB33572; BAB33572.
DR   GeneID; 29459173; -.
DR   GeneID; 913772; -.
DR   KEGG; ece:Z0156; -.
DR   KEGG; ecs:ECs0149; -.
DR   PATRIC; fig|386585.9.peg.248; -.
DR   eggNOG; ENOG4108V7X; Bacteria.
DR   eggNOG; COG1734; LUCA.
DR   HOGENOM; HOG000178407; -.
DR   KO; K06204; -.
DR   BioCyc; ECOO157:DKSA-MONOMER; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00926; DksA; 1.
DR   InterPro; IPR012784; DksA_RNA_pol-bd.
DR   InterPro; IPR037187; DnaK_N.
DR   InterPro; IPR020460; Znf_C4-type_bac.
DR   InterPro; IPR000962; Znf_DskA_TraR.
DR   InterPro; IPR020458; Znf_DskA_TraR_CS.
DR   Pfam; PF01258; zf-dskA_traR; 1.
DR   PRINTS; PR00618; DKSAZNFINGER.
DR   SUPFAM; SSF109635; SSF109635; 1.
DR   TIGRFAMs; TIGR02420; dksA; 1.
DR   PROSITE; PS01102; ZF_DKSA_1; 1.
DR   PROSITE; PS51128; ZF_DKSA_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0ABS3.
DR   SWISS-2DPAGE; P0ABS3.
KW   Coiled coil; Complete proteome; Cytoplasm; Metal-binding;
KW   Reference proteome; Zinc; Zinc-finger.
FT   CHAIN         1    151       RNA polymerase-binding transcription
FT                                factor DksA.
FT                                /FTId=PRO_0000187537.
FT   ZN_FING     114    138       dksA C4-type. {ECO:0000255|HAMAP-
FT                                Rule:MF_00926}.
FT   COILED       33     54       {ECO:0000255|HAMAP-Rule:MF_00926}.
FT   METAL       114    114       Zinc. {ECO:0000255|HAMAP-Rule:MF_00926}.
FT   METAL       117    117       Zinc. {ECO:0000255|HAMAP-Rule:MF_00926}.
FT   METAL       135    135       Zinc. {ECO:0000255|HAMAP-Rule:MF_00926}.
FT   METAL       138    138       Zinc. {ECO:0000255|HAMAP-Rule:MF_00926}.
SQ   SEQUENCE   151 AA;  17528 MW;  620842DB15E066A9 CRC64;
     MQEGQNRKTS SLSILAIAGV EPYQEKPGEE YMNEAQLAHF RRILEAWRNQ LRDEVDRTVT
     HMQDEAANFP DPVDRAAQEE EFSLELRNRD RERKLIKKIE KTLKKVEDED FGYCESCGVE
     IGIRRLEARP TADLCIDCKT LAEIREKQMA G
//

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