(data stored in ACNUC7421 zone)

SWISSPROT: Q8X906_ECO57

ID   Q8X906_ECO57            Unreviewed;       179 AA.
AC   Q8X906; Q7AHN0;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   07-JUN-2017, entry version 98.
DE   RecName: Full=RNA 2',3'-cyclic phosphodiesterase {ECO:0000256|HAMAP-Rule:MF_01940};
DE            Short=RNA 2',3'-CPDase {ECO:0000256|HAMAP-Rule:MF_01940};
DE            EC=3.1.4.- {ECO:0000256|HAMAP-Rule:MF_01940};
GN   Name=yadP {ECO:0000313|EMBL:AAG54451.1};
GN   Synonyms=thpR {ECO:0000256|HAMAP-Rule:MF_01940};
GN   OrderedLocusNames=ECs0151 {ECO:0000313|EMBL:BAB33574.1}, Z0158
GN   {ECO:0000313|EMBL:AAG54451.1};
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334 {ECO:0000313|Proteomes:UP000002519};
RN   [1] {ECO:0000313|EMBL:BAB33574.1, ECO:0000313|Proteomes:UP000000558}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC
RC   {ECO:0000313|Proteomes:UP000000558}, and Sakai
RC   {ECO:0000313|EMBL:BAB33574.1};
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [2] {ECO:0000313|EMBL:AAG54451.1, ECO:0000313|Proteomes:UP000002519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EDL933 {ECO:0000313|EMBL:AAG54451.1}, and O157:H7 / EDL933 /
RC   ATCC 700927 / EHEC {ECO:0000313|Proteomes:UP000002519};
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G.III., Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
CC   -!- FUNCTION: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-
CC       phosphomonoester. {ECO:0000256|HAMAP-Rule:MF_01940}.
CC   -!- SIMILARITY: Belongs to the 2H phosphoesterase superfamily. ThpR
CC       family. {ECO:0000256|HAMAP-Rule:MF_01940}.
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DR   EMBL; AE005174; AAG54451.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33574.1; -; Genomic_DNA.
DR   PIR; G85498; G85498.
DR   PIR; G90647; G90647.
DR   RefSeq; NP_308178.2; NC_002695.1.
DR   ProteinModelPortal; Q8X906; -.
DR   STRING; 155864.Z0158; -.
DR   EnsemblBacteria; AAG54451; AAG54451; Z0158.
DR   EnsemblBacteria; BAB33574; BAB33574; BAB33574.
DR   GeneID; 913775; -.
DR   KEGG; ece:Z0158; -.
DR   KEGG; ecs:ECs0151; -.
DR   PATRIC; fig|386585.9.peg.250; -.
DR   eggNOG; ENOG4107XID; Bacteria.
DR   eggNOG; COG1514; LUCA.
DR   HOGENOM; HOG000226389; -.
DR   KO; K01975; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0004113; F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity; IEA:InterPro.
DR   GO; GO:0008664; F:2'-5'-RNA ligase activity; IEA:InterPro.
DR   HAMAP; MF_01940; RNA_CPDase; 1.
DR   InterPro; IPR009097; cNuc_Pdiesterase.
DR   InterPro; IPR014051; Phosphoesterase_HXTX.
DR   InterPro; IPR004175; RNA_CPDase.
DR   Pfam; PF02834; LigT_PEase; 2.
DR   SUPFAM; SSF55144; SSF55144; 1.
DR   TIGRFAMs; TIGR02258; 2_5_ligase; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8X906.
DR   SWISS-2DPAGE; Q8X906.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000558,
KW   ECO:0000313|Proteomes:UP000002519};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01940}.
FT   DOMAIN       14     92       LigT_PEase. {ECO:0000259|Pfam:PF02834}.
FT   DOMAIN       95    167       LigT_PEase. {ECO:0000259|Pfam:PF02834}.
FT   MOTIF        46     49       HXTX 1. {ECO:0000256|HAMAP-Rule:
FT                                MF_01940}.
FT   MOTIF       128    131       HXTX 2. {ECO:0000256|HAMAP-Rule:
FT                                MF_01940}.
FT   ACT_SITE     46     46       Proton donor. {ECO:0000256|HAMAP-Rule:
FT                                MF_01940}.
FT   ACT_SITE    128    128       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_01940}.
SQ   SEQUENCE   179 AA;  20329 MW;  5025EBEF032463CA CRC64;
     MPHMSDPQRL FFAIDLPAEI REQIIHWRAT HFPLEAGRPV AADNLHLTLA FLGEVSAEKE
     KALSLLAGRI RQPGFTLTLD DAGQWLRSRV VWLGMRQPPR GLIQLANMLR SQAARSGCFQ
     SNRPFHPHIT LLRDASEAVT IPPPGFNWSY AVTEFTLYAS SFARGRTRYT PLKRWVLTQ
//

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