(data stored in ACNUC7421 zone)

SWISSPROT: CDSA_ECO57

ID   CDSA_ECO57              Reviewed;         285 AA.
AC   P0ABG2; P06466;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   05-JUL-2017, entry version 74.
DE   RecName: Full=Phosphatidate cytidylyltransferase;
DE            EC=2.7.7.41;
DE   AltName: Full=CDP-DAG synthase;
DE   AltName: Full=CDP-DG synthase;
DE   AltName: Full=CDP-diacylglycerol synthase;
DE            Short=CDS;
DE   AltName: Full=CDP-diglyceride pyrophosphorylase;
DE   AltName: Full=CDP-diglyceride synthase;
DE   AltName: Full=CTP:phosphatidate cytidylyltransferase;
GN   Name=cdsA; OrderedLocusNames=Z0186, ECs0177;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- CATALYTIC ACTIVITY: CTP + phosphatidate = diphosphate + CDP-
CC       diacylglycerol.
CC   -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis;
CC       CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDS family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG54477.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB33600.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; AE005174; AAG54477.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB33600.1; ALT_INIT; Genomic_DNA.
DR   PIR; A85502; A85502.
DR   PIR; A99651; A99651.
DR   RefSeq; NP_308204.2; NC_002695.1.
DR   RefSeq; WP_000922446.1; NZ_MWVM01000012.1.
DR   ProteinModelPortal; P0ABG2; -.
DR   STRING; 155864.Z0186; -.
DR   EnsemblBacteria; AAG54477; AAG54477; Z0186.
DR   EnsemblBacteria; BAB33600; BAB33600; BAB33600.
DR   GeneID; 913883; -.
DR   KEGG; ece:Z0186; -.
DR   KEGG; ecs:ECs0177; -.
DR   PATRIC; fig|386585.9.peg.280; -.
DR   eggNOG; ENOG4105KNE; Bacteria.
DR   eggNOG; COG0575; LUCA.
DR   HOGENOM; HOG000006168; -.
DR   KO; K00981; -.
DR   UniPathway; UPA00557; UER00614.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004605; F:phosphatidate cytidylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016024; P:CDP-diacylglycerol biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR000374; PC_trans.
DR   PROSITE; PS01315; CDS; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0ABG2.
DR   SWISS-2DPAGE; P0ABG2.
KW   Cell inner membrane; Cell membrane; Complete proteome;
KW   Lipid biosynthesis; Lipid metabolism; Membrane;
KW   Nucleotidyltransferase; Phospholipid biosynthesis;
KW   Phospholipid metabolism; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    285       Phosphatidate cytidylyltransferase.
FT                                /FTId=PRO_0000090735.
FT   TRANSMEM     10     30       Helical. {ECO:0000255}.
FT   TRANSMEM     56     76       Helical. {ECO:0000255}.
FT   TRANSMEM     93    113       Helical. {ECO:0000255}.
FT   TRANSMEM    121    141       Helical. {ECO:0000255}.
FT   TRANSMEM    151    171       Helical. {ECO:0000255}.
FT   TRANSMEM    190    210       Helical. {ECO:0000255}.
FT   TRANSMEM    213    233       Helical. {ECO:0000255}.
FT   TRANSMEM    264    284       Helical. {ECO:0000255}.
SQ   SEQUENCE   285 AA;  31454 MW;  0D77DCD5EC5FBA9F CRC64;
     MLKYRLISAF VLIPVVIAAL FLLPPVGFAI VTLVVCMLAA WEWGQLSGFT TRSQRVWLAV
     LCGLLLALML FLLPEYHRNI HQPLVEISLW ASLGWWIVAL LLVLFYPGSA AIWRNSKTLR
     LIFGVLTIVP FFWGMLALRA WHYDENHYSG AIWLLYVMIL VWGADSGAYM FGKLFGKHKL
     APKVSPGKTW QGFIGGLATA AVISWGYGMW ANLDVAPVTL LICSIVAALA SVLGDLTESM
     FKREAGIKDS GHLIPGHGGI LDRIDSLTAA VPVFACLLLL VFRTL
//

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