(data stored in ACNUC7421 zone)

SWISSPROT: FABZ_ECO57

ID   FABZ_ECO57              Reviewed;         151 AA.
AC   P0A6Q8; P21774;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   05-JUL-2017, entry version 76.
DE   RecName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ;
DE            EC=4.2.1.59;
DE   AltName: Full=(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase;
DE            Short=(3R)-hydroxymyristoyl-ACP dehydrase;
DE   AltName: Full=Beta-hydroxyacyl-ACP dehydratase;
GN   Name=fabZ; OrderedLocusNames=Z0192, ECs0182;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Involved in unsaturated fatty acids biosynthesis.
CC       Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and
CC       long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: A (3R)-3-hydroxyacyl-[acyl-carrier protein] =
CC       a trans-2-enoyl-[acyl-carrier protein] + H(2)O.
CC   -!- SUBUNIT: Oligomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: The N-terminus is blocked. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the thioester dehydratase family. FabZ
CC       subfamily. {ECO:0000305}.
DR   EMBL; AE005174; AAG54482.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33605.1; -; Genomic_DNA.
DR   PIR; F85502; F85502.
DR   PIR; F90651; F90651.
DR   RefSeq; NP_308209.1; NC_002695.1.
DR   RefSeq; WP_000210739.1; NZ_MWVM01000012.1.
DR   ProteinModelPortal; P0A6Q8; -.
DR   SMR; P0A6Q8; -.
DR   MINT; MINT-1218545; -.
DR   STRING; 155864.Z0192; -.
DR   EnsemblBacteria; AAG54482; AAG54482; Z0192.
DR   EnsemblBacteria; BAB33605; BAB33605; BAB33605.
DR   GeneID; 913892; -.
DR   KEGG; ece:Z0192; -.
DR   KEGG; ecs:ECs0182; -.
DR   PATRIC; fig|386585.9.peg.285; -.
DR   eggNOG; ENOG4108YXN; Bacteria.
DR   eggNOG; COG0764; LUCA.
DR   HOGENOM; HOG000277829; -.
DR   KO; K02372; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0047451; F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00406; FabZ; 1.
DR   InterPro; IPR013114; FabA_FabZ.
DR   InterPro; IPR010084; FabZ.
DR   InterPro; IPR029069; HotDog_dom.
DR   Pfam; PF07977; FabA; 1.
DR   SUPFAM; SSF54637; SSF54637; 1.
DR   TIGRFAMs; TIGR01750; fabZ; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0A6Q8.
DR   SWISS-2DPAGE; P0A6Q8.
KW   Complete proteome; Cytoplasm; Lipid A biosynthesis;
KW   Lipid biosynthesis; Lipid metabolism; Lyase.
FT   CHAIN         1    151       3-hydroxyacyl-[acyl-carrier-protein]
FT                                dehydratase FabZ.
FT                                /FTId=PRO_0000091675.
FT   ACT_SITE     54     54       {ECO:0000250}.
FT   CONFLICT     37     37       F -> L (in Ref. 2; BAB33605).
FT                                {ECO:0000305}.
SQ   SEQUENCE   151 AA;  17033 MW;  91F514A7319C2FB1 CRC64;
     MTTNTHTLQI EEILELLPHR FPFLLVDRVL DFEEGRFLRA VKNVSVNEPF FQGHFPGKPI
     FPGVLILEAM AQATGILAFK SVGKLEPGEL YYFAGIDEAR FKRPVVPGDQ MIMEVTFEKT
     RRGLTRFKGV ALVDGKVVCE ATMMCARSRE A
//

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