(data stored in ACNUC7421 zone)

SWISSPROT: IVY_ECO57

ID   IVY_ECO57               Reviewed;         157 AA.
AC   P0AD60; P45502; P77185;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   05-JUL-2017, entry version 64.
DE   RecName: Full=Inhibitor of vertebrate lysozyme;
DE   Flags: Precursor;
GN   Name=ivy; OrderedLocusNames=Z0277, ECs0247;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Strong inhibitor of lysozyme C. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ivy family. {ECO:0000305}.
DR   EMBL; AE005174; AAG54545.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33670.1; -; Genomic_DNA.
DR   PIR; E85510; E85510.
DR   PIR; G90659; G90659.
DR   RefSeq; NP_308274.1; NC_002695.1.
DR   RefSeq; WP_000532698.1; NZ_MWVM01000023.1.
DR   ProteinModelPortal; P0AD60; -.
DR   SMR; P0AD60; -.
DR   STRING; 155864.Z0277; -.
DR   PRIDE; P0AD60; -.
DR   EnsemblBacteria; AAG54545; AAG54545; Z0277.
DR   EnsemblBacteria; BAB33670; BAB33670; BAB33670.
DR   GeneID; 914333; -.
DR   KEGG; ece:Z0277; -.
DR   KEGG; ecs:ECs0247; -.
DR   PATRIC; fig|386585.9.peg.347; -.
DR   eggNOG; ENOG4108WN0; Bacteria.
DR   eggNOG; ENOG4111K9M; LUCA.
DR   HOGENOM; HOG000117011; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.
DR   InterPro; IPR014453; Ihibitor_vertebrate_lysozyme.
DR   PIRSF; PIRSF009103; Ivy; 1.
DR   SUPFAM; SSF89872; SSF89872; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0AD60.
DR   SWISS-2DPAGE; P0AD60.
KW   Complete proteome; Disulfide bond; Periplasm; Signal.
FT   SIGNAL        1     28       {ECO:0000255}.
FT   CHAIN        29    157       Inhibitor of vertebrate lysozyme.
FT                                /FTId=PRO_0000043361.
FT   DISULFID     85     90       {ECO:0000250}.
SQ   SEQUENCE   157 AA;  16872 MW;  9156C5944DFE6D84 CRC64;
     MGRISSGGMM FKAITTVAAL VIATSAMAQD DLTISSLAKG ETTKAAFNQM VQGHKLPAWV
     MKGGTYTPAQ TVTLGDETYQ VMSACKPHDC GSQRIAVMWS EKSNQMTGLF STIDEKTSQE
     KLTWLNVNDA LSIDGKTVLF AALTGSLENH PDGFNFK
//

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