(data stored in ACNUC7421 zone)

SWISSPROT: CRL_ECO57

ID   CRL_ECO57               Reviewed;         133 AA.
AC   Q8X7N6; Q7AHG1;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   05-JUL-2017, entry version 87.
DE   RecName: Full=Sigma factor-binding protein Crl {ECO:0000255|HAMAP-Rule:MF_01178};
GN   Name=crl {ECO:0000255|HAMAP-Rule:MF_01178};
GN   OrderedLocusNames=Z0301, ECs0267;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Binds to the sigma-S subunit of RNA polymerase,
CC       activating expression of sigma-S-regulated genes. Stimulates RNA
CC       polymerase holoenzyme formation and may bind to several other
CC       sigma factors, such as sigma-70 and sigma-32. {ECO:0000255|HAMAP-
CC       Rule:MF_01178}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01178}.
CC   -!- SIMILARITY: Belongs to the Crl family. {ECO:0000255|HAMAP-
CC       Rule:MF_01178}.
DR   EMBL; AE005174; AAG54565.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33690.1; -; Genomic_DNA.
DR   PIR; A85513; A85513.
DR   PIR; C90662; C90662.
DR   RefSeq; NP_308294.1; NC_002695.1.
DR   RefSeq; WP_000174701.1; NZ_MWVM01000023.1.
DR   SMR; Q8X7N6; -.
DR   STRING; 155864.Z0301; -.
DR   EnsemblBacteria; AAG54565; AAG54565; Z0301.
DR   EnsemblBacteria; BAB33690; BAB33690; BAB33690.
DR   GeneID; 914365; -.
DR   KEGG; ece:Z0301; -.
DR   KEGG; ecs:ECs0267; -.
DR   PATRIC; fig|386585.9.peg.369; -.
DR   eggNOG; ENOG4108UVK; Bacteria.
DR   eggNOG; ENOG4111IQF; LUCA.
DR   HOGENOM; HOG000282284; -.
DR   KO; K11926; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   HAMAP; MF_01178; Crl; 1.
DR   InterPro; IPR009986; Tscrpt_reg_Crl.
DR   Pfam; PF07417; Crl; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8X7N6.
DR   SWISS-2DPAGE; Q8X7N6.
KW   Activator; Coiled coil; Complete proteome; Cytoplasm; Transcription;
KW   Transcription regulation.
FT   INIT_MET      1      1       Removed. {ECO:0000250}.
FT   CHAIN         2    133       Sigma factor-binding protein Crl.
FT                                /FTId=PRO_0000268897.
FT   REGION       99    122       Essential for activity.
FT                                {ECO:0000255|HAMAP-Rule:MF_01178}.
FT   COILED       90    116       {ECO:0000255|HAMAP-Rule:MF_01178}.
SQ   SEQUENCE   133 AA;  15684 MW;  4711CC4D63C58BCA CRC64;
     MTLPSGHPKS RLIKKFTVLG PYIREGKCED NRFFFDCLAV CVNVKPAPEV REFWGWWMEL
     EAQESRFTYS YQFGLFDKAG DWKSVPVKDT EVVERLEHTL REFHEKLREL LTTLNLKLEP
     ADDFRDEPVK LTA
//

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