(data stored in ACNUC7421 zone)

SWISSPROT: YAGR_ECO57

ID   YAGR_ECO57              Reviewed;         732 AA.
AC   Q8X6J4;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 95.
DE   RecName: Full=Putative xanthine dehydrogenase YagR molybdenum-binding subunit;
DE            EC=1.17.1.4;
GN   Name=yagR; OrderedLocusNames=Z0350, ECs0314;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- CATALYTIC ACTIVITY: Xanthine + NAD(+) + H(2)O = urate + NADH.
CC   -!- CATALYTIC ACTIVITY: Hypoxanthine + NAD(+) + H(2)O = xanthine +
CC       NADH.
CC   -!- COFACTOR:
CC       Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302;
CC         Evidence={ECO:0000250};
CC       Note=Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
CC       {ECO:0000250};
CC   -!- SUBUNIT: Heterotrimer of YagR, YagS and YagT. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the xanthine dehydrogenase family.
CC       {ECO:0000305}.
DR   EMBL; AE005174; AAG54609.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33737.1; -; Genomic_DNA.
DR   PIR; B90668; B90668.
DR   PIR; E85518; E85518.
DR   RefSeq; NP_308341.1; NC_002695.1.
DR   RefSeq; WP_000667043.1; NZ_MWVM01000043.1.
DR   ProteinModelPortal; Q8X6J4; -.
DR   SMR; Q8X6J4; -.
DR   STRING; 155864.Z0350; -.
DR   EnsemblBacteria; AAG54609; AAG54609; Z0350.
DR   EnsemblBacteria; BAB33737; BAB33737; BAB33737.
DR   GeneID; 914413; -.
DR   KEGG; ece:Z0350; -.
DR   KEGG; ecs:ECs0314; -.
DR   PATRIC; fig|386585.9.peg.408; -.
DR   eggNOG; ENOG4105C7W; Bacteria.
DR   eggNOG; COG1529; LUCA.
DR   HOGENOM; HOG000244716; -.
DR   KO; K11177; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004854; F:xanthine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.365.10; -; 4.
DR   Gene3D; 3.90.1170.50; -; 1.
DR   InterPro; IPR000674; Ald_Oxase/Xan_DH_a/b.
DR   InterPro; IPR008274; AldOxase/xan_DH_Mopterin-bd.
DR   Pfam; PF01315; Ald_Xan_dh_C; 1.
DR   Pfam; PF02738; Ald_Xan_dh_C2; 1.
DR   SMART; SM01008; Ald_Xan_dh_C; 1.
DR   SUPFAM; SSF54665; SSF54665; 1.
DR   SUPFAM; SSF56003; SSF56003; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8X6J4.
DR   SWISS-2DPAGE; Q8X6J4.
KW   Complete proteome; Metal-binding; Molybdenum; NAD; Oxidoreductase;
KW   Purine metabolism; Purine salvage.
FT   CHAIN         1    732       Putative xanthine dehydrogenase YagR
FT                                molybdenum-binding subunit.
FT                                /FTId=PRO_0000166091.
FT   METAL       211    211       Molybdenum. {ECO:0000255}.
FT   METAL       242    242       Molybdenum; via carbonyl oxygen.
FT                                {ECO:0000255}.
FT   METAL       350    350       Molybdenum; via amide nitrogen.
FT                                {ECO:0000255}.
SQ   SEQUENCE   732 AA;  78135 MW;  A996E91BEB2643F6 CRC64;
     MKFDKPAGEN PIDQLKVVGR PHDRIDGPLK TTGTARYAYE WHEESPNAAY GYIVGSAIAK
     GRLTALDTDA AQKAPGVLPV ITASNAGALS KGDKNTARLL GGPTIEHYHQ AIALVVAETF
     EQARAAASLV QAHYRRNKGA YSLADEKQAV SQPPEDTPDK NVGDFDGAFS SAAVKIDATY
     TTPDQSHMAM EPHASMAVWD GNKLTLWTSN QMIDWCRTDL AKTLKVPVEN VRIISPYIGG
     GFGGKLFLRS DALLAALAAR AVKRPVKVML PRPSIPNNTT HRPATLQHLR IGADQSGKIT
     AISHESWSGN LPGGTPETAV QQSELLYAGA NRHTGLRLAT LDLPEGNAMR APGEAPGLMA
     LEIAIDELAE KAGIDPVEFR ILNDTQIDPA DPTRRFSRRQ LIECLRTGAD KFGWKQRNAT
     PGQVRDGEWL VGHGVAAGFR NNLLEKSGAR VHLEPNGTVT VETDMTDIGT GSYTILAQTA
     AEMLGVPLEQ VAVHLGDSSF PVSAGSGGQW GANTSTSGVY AACVKLREMI ASAVGFDPEQ
     SQFADGKITN GTRSAILHEA TAGGRLTAEE SIEFGTLSKE YQQSTFAGHF VEVGVHSATG
     EVRVRRMLAV CAAGRILNPK TARSQVIGAM TMGMGAALME ELAVDDRLGY FVNHDMAGYE
     VPVHADIPKQ EVIFLDDTDP ISSPMKAKGV GELGLCGVSA AIANAVYNAT GIRVRDYPIT
     LDKLLDKLPD VV
//

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