(data stored in ACNUC7421 zone)

SWISSPROT: ECPD_ECO57

ID   ECPD_ECO57              Reviewed;         547 AA.
AC   Q8X4N4; Q7AHC3;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 75.
DE   RecName: Full=Fimbria adhesin EcpD;
DE   Flags: Precursor;
GN   Name=ecpD; Synonyms=yagW; OrderedLocusNames=Z0357, ECs0320;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [3]
RP   INDUCTION.
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=22797761; DOI=10.1128/JB.00915-12;
RA   Martinez-Santos V.I., Medrano-Lopez A., Saldana Z., Giron J.A.,
RA   Puente J.L.;
RT   "Transcriptional regulation of the ecp operon by EcpR, IHF, and H-NS
RT   in attaching and effacing Escherichia coli.";
RL   J. Bacteriol. 194:5020-5033(2012).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli
CC       common pilus (ECP). ECP is found in both commensal and pathogenic
CC       strains and plays a dual role in early-stage biofilm development
CC       and host cell recognition. Tip pilus adhesin, which is required
CC       for assembly of EcpA into fibers (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms polymers. Interacts with EcpA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by
CC       IHF and EcpR. {ECO:0000269|PubMed:22797761}.
CC   -!- SIMILARITY: Belongs to the EcpD/MatE family. {ECO:0000305}.
DR   EMBL; AE005174; AAG54615.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33743.1; -; Genomic_DNA.
DR   PIR; C85519; C85519.
DR   PIR; H90668; H90668.
DR   RefSeq; NP_308347.1; NC_002695.1.
DR   RefSeq; WP_001265657.1; NZ_MWVM01000043.1.
DR   STRING; 155864.Z0357; -.
DR   EnsemblBacteria; AAG54615; AAG54615; Z0357.
DR   EnsemblBacteria; BAB33743; BAB33743; BAB33743.
DR   GeneID; 914419; -.
DR   KEGG; ece:Z0357; -.
DR   KEGG; ecs:ECs0320; -.
DR   PATRIC; fig|386585.9.peg.414; -.
DR   eggNOG; ENOG4106PYX; Bacteria.
DR   eggNOG; ENOG410YH0U; LUCA.
DR   HOGENOM; HOG000269468; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
DR   PRODOM; Q8X4N4.
DR   SWISS-2DPAGE; Q8X4N4.
KW   Complete proteome; Fimbrium; Receptor; Signal.
FT   SIGNAL        1     23       {ECO:0000255}.
FT   CHAIN        24    547       Fimbria adhesin EcpD.
FT                                /FTId=PRO_0000429535.
SQ   SEQUENCE   547 AA;  60007 MW;  C38EB4EDE4E8C08E CRC64;
     MRVNLLIAMI IFALIWPVTA LRAAVSKTTW ADAPAREFVF VENNSDDNFF VTPGGALDPR
     LTGANRWTGL KYNGSGTIYQ QSLGYIDNGY NTGLYTNWKF DMWLENSPVS SPLTGLRCIN
     WYAGCNMTTS LILPQTTDTS GFYGATVTSG GAKWMHGMLS DAFYQYLQQM PVGSSFTMTI
     NACQTSVNYD ASSGARCKDQ ASGNWYVRNV THTKAANLRL INTHSLAEVF INSDGVPTLG
     EGNADCRTQT IGSRSGLSCK MVNYTLQTNG LSNTSIHIFP AIANSSLASA VGAYDMQFSL
     NGSSWKPVSN TAYYYTFNEM KSADSIYVFF SSNFFKQMVN QGISDINTKD LFNFRFQNTT
     SPESGWYEFS TSNTLIIKPR DFSISIISDE YTQTPSREGY VGSGESALDF GYIVTTSGKT
     AADEVLIKVT GPAQVIGGRS YCVFSSDDGK AKVPFPATLS FITRNGATKT YDAGCDDSWR
     DMTDALWLTT PWTDISGEVG QMDKTTVKFS IPMDNAISLR TVDDNGWFGE VSASGEIHVQ
     ATWRNIN
//

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