(data stored in ACNUC7421 zone)

SWISSPROT: ECPR_ECO57

ID   ECPR_ECO57              Reviewed;         196 AA.
AC   Q8X6I1; Q7AHC0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 103.
DE   RecName: Full=HTH-type transcriptional regulator EcpR;
GN   Name=ecpR; Synonyms=matA; OrderedLocusNames=Z0361, ECs0324;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [3]
RP   FUNCTION, DNA-BINDING, AND INDUCTION.
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=22797761; DOI=10.1128/JB.00915-12;
RA   Martinez-Santos V.I., Medrano-Lopez A., Saldana Z., Giron J.A.,
RA   Puente J.L.;
RT   "Transcriptional regulation of the ecp operon by EcpR, IHF, and H-NS
RT   in attaching and effacing Escherichia coli.";
RL   J. Bacteriol. 194:5020-5033(2012).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli
CC       common pilus (ECP). ECP is found in both commensal and pathogenic
CC       strains and plays a dual role in early-stage biofilm development
CC       and host cell recognition (By similarity). Positively regulates
CC       the expression of the ecp operon by binding to two TTCCT boxes.
CC       {ECO:0000250, ECO:0000269|PubMed:22797761}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively autoregulated.
CC       Also positively regulated by IHF. {ECO:0000269|PubMed:22797761}.
CC   -!- SIMILARITY: Belongs to the EcpR/MatA family. {ECO:0000305}.
DR   EMBL; AE005174; AAG54619.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33747.1; -; Genomic_DNA.
DR   PIR; D90669; D90669.
DR   PIR; G85519; G85519.
DR   RefSeq; NP_308351.1; NC_002695.1.
DR   RefSeq; WP_000220212.1; NZ_MWVM01000043.1.
DR   ProteinModelPortal; Q8X6I1; -.
DR   SMR; Q8X6I1; -.
DR   STRING; 155864.Z0361; -.
DR   EnsemblBacteria; AAG54619; AAG54619; Z0361.
DR   EnsemblBacteria; BAB33747; BAB33747; BAB33747.
DR   GeneID; 914423; -.
DR   KEGG; ece:Z0361; -.
DR   KEGG; ecs:ECs0324; -.
DR   PATRIC; fig|386585.9.peg.418; -.
DR   eggNOG; ENOG4106JB4; Bacteria.
DR   eggNOG; ENOG410Y9ZI; LUCA.
DR   HOGENOM; HOG000059412; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q8X6I1.
DR   SWISS-2DPAGE; Q8X6I1.
KW   Activator; Complete proteome; Cytoplasm; DNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    196       HTH-type transcriptional regulator EcpR.
FT                                /FTId=PRO_0000369179.
FT   DOMAIN      138    196       HTH luxR-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00411}.
FT   DNA_BIND    162    181       H-T-H motif. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00411}.
SQ   SEQUENCE   196 AA;  23300 MW;  44654EFCB47F11EB CRC64;
     MTWQNDYSRD YEVENHMECQ NRSDKYIWSP HDAYFYKGLS ELIVDIDRLI YLSLEKIRKD
     FVFINLNTDS LTEFINRDNE WLSAVKGKQV VLIAARKSEA LANYWYYNSN IRGVVYAGLS
     RDIRKELAYV INGRFLRKDI KKDKITDREM EIIRMTAQGM LPKSIARIEN CSVKTVYTHR
     RNAEAKLYSK LYKLVQ
//

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