(data stored in ACNUC7421 zone)

SWISSPROT: BETI_ECO57

ID   BETI_ECO57              Reviewed;         195 AA.
AC   Q8X6C3;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 93.
DE   RecName: Full=HTH-type transcriptional regulator BetI {ECO:0000255|HAMAP-Rule:MF_00768};
GN   Name=betI {ECO:0000255|HAMAP-Rule:MF_00768};
GN   OrderedLocusNames=Z0400, ECs0359;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Repressor involved in the biosynthesis of the
CC       osmoprotectant glycine betaine. It represses transcription of the
CC       choline transporter BetT and the genes of BetAB involved in the
CC       synthesis of glycine betaine (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway [regulation].
DR   EMBL; AE005174; AAG54655.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33782.1; -; Genomic_DNA.
DR   PIR; C85524; C85524.
DR   PIR; G90673; G90673.
DR   RefSeq; NP_308386.3; NC_002695.1.
DR   RefSeq; WP_001301903.1; NZ_MWVM01000022.1.
DR   ProteinModelPortal; Q8X6C3; -.
DR   SMR; Q8X6C3; -.
DR   STRING; 155864.Z0400; -.
DR   EnsemblBacteria; AAG54655; AAG54655; Z0400.
DR   EnsemblBacteria; BAB33782; BAB33782; BAB33782.
DR   GeneID; 914460; -.
DR   KEGG; ece:Z0400; -.
DR   KEGG; ecs:ECs0359; -.
DR   PATRIC; fig|386585.9.peg.451; -.
DR   eggNOG; ENOG4108MHR; Bacteria.
DR   eggNOG; COG1309; LUCA.
DR   HOGENOM; HOG000248227; -.
DR   KO; K02167; -.
DR   UniPathway; UPA00529; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   HAMAP; MF_00768; HTH_type_BetI; 1.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR011075; Tet_transcr_reg_TetR-rel_C.
DR   InterPro; IPR017757; Tscrpt_rep_BetI.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   TIGRFAMs; TIGR03384; betaine_BetI; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8X6C3.
DR   SWISS-2DPAGE; Q8X6C3.
KW   Complete proteome; DNA-binding; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    195       HTH-type transcriptional regulator BetI.
FT                                /FTId=PRO_0000070582.
FT   DOMAIN        8     68       HTH tetR-type. {ECO:0000255|HAMAP-
FT                                Rule:MF_00768}.
FT   DNA_BIND     31     50       H-T-H motif. {ECO:0000255|HAMAP-
FT                                Rule:MF_00768}.
SQ   SEQUENCE   195 AA;  21799 MW;  69F70443A605E4C4 CRC64;
     MPKLGMQSIR RRQLIDATLE AINEVGMHDA TIAQIARRAG VSTGIISHYF RDKNGLLEAT
     MRDITSQLRD AVLNRLHALP QGSAEQRLQA IVGGNFDETQ VSSAAMKAWL AFWASSMHQP
     MLYRLQQVSS RRLLSNLVSE FRRELPRHQA QEAGYGLAAL IDGLWLRAAL SGKPLDKPLA
     HSLTRHFITQ HLPTD
//

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