(data stored in ACNUC7421 zone)

SWISSPROT: BETT_ECO57

ID   BETT_ECO57              Reviewed;         677 AA.
AC   P0ABD0; P17447;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   05-JUL-2017, entry version 81.
DE   RecName: Full=High-affinity choline transport protein;
GN   Name=betT; OrderedLocusNames=Z0401, ECs0360;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: High-affinity uptake of choline driven by a proton-
CC       motive force. {ECO:0000250}.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- INDUCTION: By osmotic stress. Choline is required for full
CC       expression (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BCCT transporter (TC 2.A.15) family.
CC       {ECO:0000305}.
DR   EMBL; AE005174; AAG54656.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33783.1; -; Genomic_DNA.
DR   PIR; D85524; D85524.
DR   PIR; H90673; H90673.
DR   RefSeq; NP_308387.1; NC_002695.1.
DR   RefSeq; WP_000131044.1; NZ_MWVM01000022.1.
DR   ProteinModelPortal; P0ABD0; -.
DR   STRING; 155864.Z0401; -.
DR   EnsemblBacteria; AAG54656; AAG54656; Z0401.
DR   EnsemblBacteria; BAB33783; BAB33783; BAB33783.
DR   GeneID; 914461; -.
DR   KEGG; ece:Z0401; -.
DR   KEGG; ecs:ECs0360; -.
DR   PATRIC; fig|386585.9.peg.452; -.
DR   eggNOG; ENOG4105C94; Bacteria.
DR   eggNOG; COG1292; LUCA.
DR   HOGENOM; HOG000053241; -.
DR   KO; K02168; -.
DR   UniPathway; UPA00529; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005215; F:transporter activity; IEA:InterPro.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR018093; BCCT_CS.
DR   InterPro; IPR000060; BCCT_transptr.
DR   PANTHER; PTHR30047; PTHR30047; 1.
DR   Pfam; PF02028; BCCT; 1.
DR   TIGRFAMs; TIGR00842; bcct; 1.
DR   PROSITE; PS01303; BCCT; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0ABD0.
DR   SWISS-2DPAGE; P0ABD0.
KW   Cell inner membrane; Cell membrane; Complete proteome; Membrane;
KW   Stress response; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    677       High-affinity choline transport protein.
FT                                /FTId=PRO_0000201485.
FT   TRANSMEM     15     35       Helical. {ECO:0000255}.
FT   TRANSMEM     54     74       Helical. {ECO:0000255}.
FT   TRANSMEM     94    114       Helical. {ECO:0000255}.
FT   TRANSMEM    144    164       Helical. {ECO:0000255}.
FT   TRANSMEM    196    216       Helical. {ECO:0000255}.
FT   TRANSMEM    233    253       Helical. {ECO:0000255}.
FT   TRANSMEM    265    285       Helical. {ECO:0000255}.
FT   TRANSMEM    319    339       Helical. {ECO:0000255}.
FT   TRANSMEM    350    370       Helical. {ECO:0000255}.
FT   TRANSMEM    412    432       Helical. {ECO:0000255}.
FT   TRANSMEM    452    472       Helical. {ECO:0000255}.
FT   TRANSMEM    477    497       Helical. {ECO:0000255}.
SQ   SEQUENCE   677 AA;  75842 MW;  76062FCE877D0A55 CRC64;
     MTDLSHSREK DKINPVVFYT SAGLILLFSL TTILFRDFSA LWIGRTLDWV SKTFGWYYLL
     AATLYIVFVV CIACSRFGSV KLGPEQSKPE FSLLSWAAML FAAGIGIDLM FFSVAEPVTQ
     YMQPPEGAGQ TIEAARQAMV WTLFHYGLTG WSMYALMGMA LGYFSYRYNL PLTIRSALYP
     IFGKRINGPI GHSVDIAAVI GTIFGIATTL GIGVVQLNYG LSVLFDIPDS MAAKAALIAL
     SVIIATISVT SGVDKGIRVL SELNVALALG LILFVLFMGD TSFLLNALVL NVGDYVNRFM
     GMTLNSFAFD RPVEWMNNWT LFFWAWWVAW SPFVGLFLAR ISRGRTIRQF VLGTLIIPFT
     FTLLWLSVFG NSALYEIIHG GAAFAEEAMV HPERGFYSLL AQYPAFTFSA SVATITGLLF
     YVTSADSGAL VLGNFTSQLK DINSDAPGWL RVFWSVAIGL LTLGMLMTNG ISALQNTTVI
     MGLPFSFVIF FVMAGLYKSL KVEDYRRESA NRDTAPRPLG LQDRLSWKKR LSRLMNYPGT
     RYTKQMMETV CYPAMEEVAQ ELRLRGAYVE LKSLPPEEGQ QLGHLDLLVH MGEEQNFVYQ
     IWPQQYSVPG FTYRARSGKS TYYRLETFLL EGSQGNDLMD YSKEQVITDI LDQYERHLNF
     IHLHREAPGH SVMFPDA
//

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