(data stored in ACNUC7421 zone)

SWISSPROT: CODB_ECO57

ID   CODB_ECO57              Reviewed;         419 AA.
AC   Q8X691; Q7AH64;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 92.
DE   RecName: Full=Cytosine permease;
GN   Name=codB; OrderedLocusNames=Z0432, ECs0389;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Required for cytosine transport into the cell.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39)
CC       family. {ECO:0000305}.
DR   EMBL; AE005174; AAG54685.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33812.1; -; Genomic_DNA.
DR   PIR; A85528; A85528.
DR   PIR; E90677; E90677.
DR   RefSeq; NP_308416.1; NC_002695.1.
DR   RefSeq; WP_000076226.1; NZ_MWVM01000022.1.
DR   ProteinModelPortal; Q8X691; -.
DR   STRING; 155864.Z0432; -.
DR   EnsemblBacteria; AAG54685; AAG54685; Z0432.
DR   EnsemblBacteria; BAB33812; BAB33812; BAB33812.
DR   GeneID; 914491; -.
DR   KEGG; ece:Z0432; -.
DR   KEGG; ecs:ECs0389; -.
DR   PATRIC; fig|386585.9.peg.484; -.
DR   eggNOG; ENOG4105DQW; Bacteria.
DR   eggNOG; COG1457; LUCA.
DR   HOGENOM; HOG000117411; -.
DR   KO; K10974; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015209; F:cytosine transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0019858; P:cytosine metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR030191; CodB.
DR   InterPro; IPR001248; Pur-cyt_permease.
DR   PANTHER; PTHR30569; PTHR30569; 1.
DR   Pfam; PF02133; Transp_cyt_pur; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8X691.
DR   SWISS-2DPAGE; Q8X691.
KW   Cell inner membrane; Cell membrane; Complete proteome;
KW   Cytosine metabolism; Membrane; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN         1    419       Cytosine permease.
FT                                /FTId=PRO_0000197933.
FT   TOPO_DOM      1     19       Cytoplasmic. {ECO:0000305}.
FT   TRANSMEM     20     39       Helical; Name=1. {ECO:0000305}.
FT   TOPO_DOM     40     51       Periplasmic. {ECO:0000305}.
FT   TRANSMEM     52     71       Helical; Name=2. {ECO:0000305}.
FT   TOPO_DOM     72    100       Cytoplasmic. {ECO:0000305}.
FT   TRANSMEM    101    120       Helical; Name=3. {ECO:0000305}.
FT   TOPO_DOM    121    127       Periplasmic. {ECO:0000305}.
FT   TRANSMEM    128    147       Helical; Name=4. {ECO:0000305}.
FT   TOPO_DOM    148    152       Cytoplasmic. {ECO:0000305}.
FT   TRANSMEM    153    172       Helical; Name=5. {ECO:0000305}.
FT   TOPO_DOM    173    192       Periplasmic. {ECO:0000305}.
FT   TRANSMEM    193    212       Helical; Name=6. {ECO:0000305}.
FT   TOPO_DOM    213    221       Cytoplasmic. {ECO:0000305}.
FT   TRANSMEM    222    242       Helical; Name=7. {ECO:0000305}.
FT   TOPO_DOM    243    257       Periplasmic. {ECO:0000305}.
FT   TRANSMEM    258    277       Helical; Name=8. {ECO:0000305}.
FT   TOPO_DOM    278    300       Cytoplasmic. {ECO:0000305}.
FT   TRANSMEM    301    320       Helical; Name=9. {ECO:0000305}.
FT   TOPO_DOM    321    321       Periplasmic. {ECO:0000305}.
FT   TRANSMEM    322    341       Helical; Name=10. {ECO:0000305}.
FT   TOPO_DOM    342    358       Cytoplasmic. {ECO:0000305}.
FT   TRANSMEM    359    378       Helical; Name=11. {ECO:0000305}.
FT   TOPO_DOM    379    380       Periplasmic. {ECO:0000305}.
FT   TRANSMEM    381    400       Helical; Name=12. {ECO:0000305}.
FT   TOPO_DOM    401    419       Cytoplasmic. {ECO:0000305}.
SQ   SEQUENCE   419 AA;  43664 MW;  CC4D64BD88827D93 CRC64;
     MSQDNNFSQG PVPQSARKGV LALTFVMLGL TFFSASMWTG GTLGTGLSYH DFFLAVLIGN
     LLLGIYTSFL GYIGAKTGLT THLLARFSFG VKGSWLPSLL LGGTQVGWFG VGVAMFAIPV
     GKATGLDINL LIAVSGLLMT VTVFFGISAL TVLSLIAVPA IACLGGYSVW LAVNGMGGLD
     ALKAVVPAQP LDFNVALALV VGSFISAGTL TADFVRFGRN AKLAVLVAMV AFFLGNSLMF
     IFGAAGAAAL GMADISDVMI AQGLLLPAIV VLGLNIWTTN DNALYASGLG FANITGMSSK
     TLSVINGIIG TVCALWLYNN FVGWLTFLSA AIPPVGGVII ADYLMNRRRY EHFATTRMMS
     VNWVAILAVA LGIAAGHWLP GIVPVNAVLG GALSYLILNP ILNRKTTAAM THVEANSVE
//

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