(data stored in ACNUC7421 zone)

SWISSPROT: CYNR_ECO57

ID   CYNR_ECO57              Reviewed;         299 AA.
AC   Q8X4M5; Q7AH62;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 110.
DE   RecName: Full=HTH-type transcriptional regulator CynR;
DE   AltName: Full=Cyn operon transcriptional activator;
GN   Name=cynR; OrderedLocusNames=Z0434, ECs0391;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Positively regulates the cynTSX operon, and negatively
CC       regulates its own transcription. Binds specifically to the cynR-
CC       cynTSX intergenic region (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
DR   EMBL; AE005174; AAG54687.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33814.1; -; Genomic_DNA.
DR   PIR; C85528; C85528.
DR   PIR; G90677; G90677.
DR   RefSeq; NP_308418.1; NC_002695.1.
DR   RefSeq; WP_000952470.1; NZ_MWVM01000022.1.
DR   ProteinModelPortal; Q8X4M5; -.
DR   SMR; Q8X4M5; -.
DR   STRING; 155864.Z0434; -.
DR   EnsemblBacteria; AAG54687; AAG54687; Z0434.
DR   EnsemblBacteria; BAB33814; BAB33814; BAB33814.
DR   GeneID; 914493; -.
DR   KEGG; ece:Z0434; -.
DR   KEGG; ecs:ECs0391; -.
DR   PATRIC; fig|386585.9.peg.486; -.
DR   eggNOG; ENOG4105DND; Bacteria.
DR   eggNOG; ENOG410YUCG; LUCA.
DR   HOGENOM; HOG000233514; -.
DR   KO; K11921; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8X4M5.
DR   SWISS-2DPAGE; Q8X4M5.
KW   Activator; Complete proteome; Cytoplasm; DNA-binding; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN         1    299       HTH-type transcriptional regulator CynR.
FT                                /FTId=PRO_0000309315.
FT   DOMAIN        1     58       HTH lysR-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00253}.
FT   DNA_BIND     18     37       H-T-H motif. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00253}.
SQ   SEQUENCE   299 AA;  32971 MW;  AF8253F586083A60 CRC64;
     MLSRHINYFL AVAEHGSFTR AASALHVSQP ALSQQIRQLE ESLGVPLFDR SGRTIHLTDA
     GEVWRQYASR ALQELGAGKR AIHDVADLTR GSLRIAVTPT FTSYFIGPLM ADFYARYPGI
     TLQLQEMSQE KIEDLLCRDE LDVGIAFAPV HLPELEAIPL LTESLALVVA QHHPLAACEQ
     VALSRLHDEK LVLLSAEFAT REQIDHYCEK AGLHPQVVIE ANSISAVLEL IRRTSLSTLL
     PAAIATQHDG LKAIPLAPPL LERTAVLLRR KNSWQTAAAK AFLHMALEEC ADVGENESR
//

If you have problems or comments...

PBIL Back to PBIL home page