(data stored in ACNUC7421 zone)

SWISSPROT: ACDH_ECO57

ID   ACDH_ECO57              Reviewed;         316 AA.
AC   Q8X5J9; Q7AH50;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 103.
DE   RecName: Full=Acetaldehyde dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01657};
DE            EC=1.2.1.10 {ECO:0000255|HAMAP-Rule:MF_01657};
DE   AltName: Full=Acetaldehyde dehydrogenase [acetylating] {ECO:0000255|HAMAP-Rule:MF_01657};
GN   Name=mhpF {ECO:0000255|HAMAP-Rule:MF_01657};
GN   OrderedLocusNames=Z0450, ECs0406;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Catalyzes the conversion of acetaldehyde to acetyl-CoA,
CC       using NAD(+) and coenzyme A. Is the final enzyme in the meta-
CC       cleavage pathway for the degradation of aromatic compounds.
CC       {ECO:0000255|HAMAP-Rule:MF_01657}.
CC   -!- CATALYTIC ACTIVITY: Acetaldehyde + CoA + NAD(+) = acetyl-CoA +
CC       NADH. {ECO:0000255|HAMAP-Rule:MF_01657}.
CC   -!- PATHWAY: Aromatic compound metabolism; 3-phenylpropanoate
CC       degradation. {ECO:0000255|HAMAP-Rule:MF_01657}.
CC   -!- SUBUNIT: Interacts with MhpE. {ECO:0000255|HAMAP-Rule:MF_01657}.
CC   -!- SIMILARITY: Belongs to the acetaldehyde dehydrogenase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01657}.
DR   EMBL; AE005174; AAG54702.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33829.1; -; Genomic_DNA.
DR   PIR; B85530; B85530.
DR   PIR; F90679; F90679.
DR   RefSeq; NP_308433.1; NC_002695.1.
DR   RefSeq; WP_000044300.1; NZ_MWVM01000022.1.
DR   ProteinModelPortal; Q8X5J9; -.
DR   SMR; Q8X5J9; -.
DR   STRING; 155864.Z0450; -.
DR   EnsemblBacteria; AAG54702; AAG54702; Z0450.
DR   EnsemblBacteria; BAB33829; BAB33829; BAB33829.
DR   GeneID; 914508; -.
DR   KEGG; ece:Z0450; -.
DR   KEGG; ecs:ECs0406; -.
DR   PATRIC; fig|386585.9.peg.501; -.
DR   eggNOG; ENOG4105DIV; Bacteria.
DR   eggNOG; COG4569; LUCA.
DR   HOGENOM; HOG000052149; -.
DR   KO; K04073; -.
DR   UniPathway; UPA00714; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0019380; P:3-phenylpropionate catabolic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_01657; Ac_ald_DH_ac; 1.
DR   InterPro; IPR003361; Acetaldehyde_dehydrogenase.
DR   InterPro; IPR015426; Acetylaldehyde_DH_C.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR   Pfam; PF09290; AcetDehyd-dimer; 1.
DR   Pfam; PF01118; Semialdhyde_dh; 1.
DR   PIRSF; PIRSF015689; Actaldh_dh_actl; 1.
DR   SMART; SM00859; Semialdhyde_dh; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR03215; ac_ald_DH_ac; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8X5J9.
DR   SWISS-2DPAGE; Q8X5J9.
KW   Aromatic hydrocarbons catabolism; Complete proteome; NAD;
KW   Oxidoreductase.
FT   CHAIN         1    316       Acetaldehyde dehydrogenase.
FT                                /FTId=PRO_0000337980.
FT   NP_BIND      11     14       NAD. {ECO:0000255|HAMAP-Rule:MF_01657}.
FT   NP_BIND     162    170       NAD. {ECO:0000255|HAMAP-Rule:MF_01657}.
FT   ACT_SITE    131    131       Acyl-thioester intermediate.
FT                                {ECO:0000255|HAMAP-Rule:MF_01657}.
FT   BINDING     289    289       NAD. {ECO:0000255|HAMAP-Rule:MF_01657}.
SQ   SEQUENCE   316 AA;  33587 MW;  6709FAC7425DFFB5 CRC64;
     MSKRKVAIIG SGNIGTDLMI KILRHDQHLE MAVMVGIDPQ SDGLARARRM GVATTHEGVI
     GLMNMPEFAD IDIVFDATSA GAHVKNDAAL REAKPDIRLI DLTPAAIGPY CVPVVNLEEN
     VDQLNVNMVT CGGQATIPMV AAVSRVVRVH YAEIIASIAS KSAGPGTRAN IDEFTETTSR
     AIEVVGGAAK GKAIIVLNPA EPPLMMRDTV YVLSDEASQD DIEASINEMA EAVQAYVPGY
     RLKQRVQFEV IPQDKPVNLP GVGQFSGLKT AVWLEVEGAA HYLPAYAGNL DIMTSSALAT
     AEKMAQSLAR KAGEAA
//

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