(data stored in ACNUC7421 zone)

SWISSPROT: PHOB_ECO57

ID   PHOB_ECO57              Reviewed;         229 AA.
AC   P0AFJ6; P08402;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   30-AUG-2017, entry version 85.
DE   RecName: Full=Phosphate regulon transcriptional regulatory protein PhoB;
GN   Name=phoB; OrderedLocusNames=Z0497, ECs0449;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: This protein is a positive regulator for the phosphate
CC       regulon. Transcription of this operon is positively regulated by
CC       PhoB and PhoR when phosphate is limited (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated by PhoR or CreC. {ECO:0000250}.
DR   EMBL; AE005174; AAG54745.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33872.1; -; Genomic_DNA.
DR   PIR; A99685; A99685.
DR   PIR; E85535; E85535.
DR   RefSeq; NP_308476.1; NC_002695.1.
DR   RefSeq; WP_000113933.1; NZ_MWVM01000009.1.
DR   ProteinModelPortal; P0AFJ6; -.
DR   SMR; P0AFJ6; -.
DR   STRING; 155864.Z0497; -.
DR   EnsemblBacteria; AAG54745; AAG54745; Z0497.
DR   EnsemblBacteria; BAB33872; BAB33872; BAB33872.
DR   GeneID; 914551; -.
DR   KEGG; ece:Z0497; -.
DR   KEGG; ecs:ECs0449; -.
DR   PATRIC; fig|386585.9.peg.547; -.
DR   eggNOG; ENOG4105CK6; Bacteria.
DR   eggNOG; COG0745; LUCA.
DR   HOGENOM; HOG000034819; -.
DR   KO; K07657; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR   GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   CDD; cd00156; REC; 1.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR011879; Sig_transdc_resp-reg_PhoB.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   TIGRFAMs; TIGR02154; PhoB; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0AFJ6.
DR   SWISS-2DPAGE; P0AFJ6.
KW   Activator; Complete proteome; Cytoplasm; DNA-binding;
KW   Phosphate transport; Phosphoprotein; Transcription;
KW   Transcription regulation; Transport; Two-component regulatory system.
FT   CHAIN         1    229       Phosphate regulon transcriptional
FT                                regulatory protein PhoB.
FT                                /FTId=PRO_0000081187.
FT   DOMAIN        4    120       Response regulatory.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00169}.
FT   DNA_BIND    129    227       OmpR/PhoB-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01091}.
FT   MOD_RES      53     53       4-aspartylphosphate.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00169}.
SQ   SEQUENCE   229 AA;  26433 MW;  EB46BA282F1F2C23 CRC64;
     MARRILVVED EAPIREMVCF VLEQNGFQPV EAEDYDSAVN QLNEPWPDLI LLDWMLPGGS
     GIQFIKHLKR ESMTRDIPVV MLTARGEEED RVRGLETGAD DYITKPFSPK ELVARIKAVM
     RRISPMAVEE VIEMQGLSLD PTSHRVMAGE EPLEMGPTEF KLLHFFMTHP ERVYSREQLL
     NHVWGTNVYV EDRTVDVHIR RLRKALEPGG HDRMVQTVRG TGYRFSTRF
//

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