(data stored in ACNUC7421 zone)

SWISSPROT: PROY_ECO57

ID   PROY_ECO57              Reviewed;         457 AA.
AC   P0AAE4; P77327;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   05-JUL-2017, entry version 75.
DE   RecName: Full=Proline-specific permease ProY;
GN   Name=proY; OrderedLocusNames=Z0500, ECs0452;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Permease that is involved in the transport across the
CC       cytoplasmic membrane of proline. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
CC       {ECO:0000305}.
DR   EMBL; AE005174; AAG54748.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33875.1; -; Genomic_DNA.
DR   PIR; D90685; D90685.
DR   PIR; H85535; H85535.
DR   RefSeq; NP_308479.1; NC_002695.1.
DR   RefSeq; WP_001295329.1; NZ_MWVM01000009.1.
DR   ProteinModelPortal; P0AAE4; -.
DR   STRING; 155864.Z0500; -.
DR   PRIDE; P0AAE4; -.
DR   EnsemblBacteria; AAG54748; AAG54748; Z0500.
DR   EnsemblBacteria; BAB33875; BAB33875; BAB33875.
DR   GeneID; 914554; -.
DR   KEGG; ece:Z0500; -.
DR   KEGG; ecs:ECs0452; -.
DR   PATRIC; fig|386585.9.peg.552; -.
DR   eggNOG; ENOG4105C85; Bacteria.
DR   eggNOG; COG1113; LUCA.
DR   HOGENOM; HOG000261849; -.
DR   KO; K11736; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015171; F:amino acid transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   InterPro; IPR004840; Amoino_acid_permease_CS.
DR   Pfam; PF00324; AA_permease; 1.
DR   PIRSF; PIRSF006060; AA_transporter; 1.
DR   PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0AAE4.
DR   SWISS-2DPAGE; P0AAE4.
KW   Amino-acid transport; Cell inner membrane; Cell membrane;
KW   Complete proteome; Membrane; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN         1    457       Proline-specific permease ProY.
FT                                /FTId=PRO_0000054208.
FT   TOPO_DOM      1     17       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     18     38       Helical. {ECO:0000255}.
FT   TRANSMEM     39     59       Helical. {ECO:0000255}.
FT   TOPO_DOM     60     84       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     85    105       Helical. {ECO:0000255}.
FT   TOPO_DOM    106    113       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    114    134       Helical. {ECO:0000255}.
FT   TOPO_DOM    135    156       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    157    177       Helical. {ECO:0000255}.
FT   TOPO_DOM    178    197       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    198    218       Helical. {ECO:0000255}.
FT   TOPO_DOM    219    242       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    243    263       Helical. {ECO:0000255}.
FT   TOPO_DOM    264    277       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    278    298       Helical. {ECO:0000255}.
FT   TOPO_DOM    299    331       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    332    352       Helical. {ECO:0000255}.
FT   TOPO_DOM    353    355       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    356    376       Helical. {ECO:0000255}.
FT   TOPO_DOM    377    399       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    400    420       Helical. {ECO:0000255}.
FT   TOPO_DOM    421    424       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    425    445       Helical. {ECO:0000255}.
FT   TOPO_DOM    446    457       Cytoplasmic. {ECO:0000255}.
SQ   SEQUENCE   457 AA;  50216 MW;  5F2819526EA06BD8 CRC64;
     MESKNKLKRG LSTRHIRFMA LGSAIGTGLF YGSADAIKMA GPSVLLAYII GGIAAYIIMR
     ALGEMSVHNP AASSFSRYAQ ENLGPLAGYI TGWTYCFEIL IVAIADVTAF GIYMGVWFPT
     VPHWIWVLSV VLIICAVNLM SVKVFGELEF WFSFFKVATI IIMIVAGFGI IIWGIGNGGQ
     PTGIHNLWSN GGFFSNGWLG MVMSLQMVMF AYGGIEIIGI TAGEAKDPEK SIPRAINSVP
     MRILVFYVGT LFVIMSIYPW NQVGTAGSPF VLTFQHMGIT FAASILNFVV LTASLSAINS
     DVFGVGRMLH GMAEQGSAPK IFSKTSRRGI PWVTVLVMTT ALLFAVYLNY IMPENVFLVI
     ASLATFATVW VWIMILLSQI AFRRRLPPEE VKALKFKVPG GVATTIGGLI FLLFIIGLIG
     YHPDTRISLY VGFAWIVVLL IGWMFKRRHD RQLAENQ
//

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