(data stored in ACNUC7421 zone)

SWISSPROT: SECD_ECO57

ID   SECD_ECO57              Reviewed;         615 AA.
AC   P0AG91; P19673; P72348; P77531;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   05-JUL-2017, entry version 80.
DE   RecName: Full=Protein translocase subunit SecD {ECO:0000255|HAMAP-Rule:MF_01463};
GN   Name=secD {ECO:0000255|HAMAP-Rule:MF_01463};
GN   OrderedLocusNames=Z0507, ECs0459;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Part of the Sec protein translocase complex. Interacts
CC       with the SecYEG preprotein conducting channel. SecDF uses the
CC       proton motive force (PMF) to complete protein translocation after
CC       the ATP-dependent function of SecA. {ECO:0000255|HAMAP-
CC       Rule:MF_01463}.
CC   -!- SUBUNIT: Forms a complex with SecF. Part of the essential Sec
CC       protein translocation apparatus which comprises SecA, SecYEG and
CC       auxiliary proteins SecDF-YajC and YidC. {ECO:0000255|HAMAP-
CC       Rule:MF_01463}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01463}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01463}.
CC   -!- SIMILARITY: Belongs to the SecD/SecF family. SecD subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01463}.
DR   EMBL; AE005174; AAG54755.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33882.1; -; Genomic_DNA.
DR   PIR; C90686; C90686.
DR   PIR; G85536; G85536.
DR   RefSeq; NP_308486.1; NC_002695.1.
DR   RefSeq; WP_000934822.1; NZ_MWVM01000009.1.
DR   ProteinModelPortal; P0AG91; -.
DR   SMR; P0AG91; -.
DR   STRING; 155864.Z0507; -.
DR   PRIDE; P0AG91; -.
DR   EnsemblBacteria; AAG54755; AAG54755; Z0507.
DR   EnsemblBacteria; BAB33882; BAB33882; BAB33882.
DR   GeneID; 914561; -.
DR   KEGG; ece:Z0507; -.
DR   KEGG; ecs:ECs0459; -.
DR   PATRIC; fig|386585.9.peg.559; -.
DR   eggNOG; ENOG4107QN8; Bacteria.
DR   eggNOG; COG0342; LUCA.
DR   HOGENOM; HOG000018637; -.
DR   KO; K03072; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015450; F:P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   HAMAP; MF_01463_B; SecD_B; 1.
DR   InterPro; IPR005791; SecD.
DR   InterPro; IPR027398; SecD-TM.
DR   InterPro; IPR022813; SecD/SecF_arch_bac.
DR   InterPro; IPR022645; SecD/SecF_bac.
DR   InterPro; IPR022646; SecD/SecF_CS.
DR   Pfam; PF07549; Sec_GG; 1.
DR   Pfam; PF13721; SecD-TM1; 1.
DR   Pfam; PF02355; SecD_SecF; 1.
DR   TIGRFAMs; TIGR00916; 2A0604s01; 1.
DR   TIGRFAMs; TIGR01129; secD; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0AG91.
DR   SWISS-2DPAGE; P0AG91.
KW   Cell inner membrane; Cell membrane; Complete proteome; Membrane;
KW   Protein transport; Translocation; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN         1    615       Protein translocase subunit SecD.
FT                                /FTId=PRO_0000095961.
FT   TOPO_DOM      1      9       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     10     29       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01463}.
FT   TOPO_DOM     30    455       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    456    472       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01463}.
FT   TOPO_DOM    473    476       Cytoplasmic. {ECO:0000255}.
FT   TOPO_DOM    498    501       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    502    518       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01463}.
FT   TOPO_DOM    519    563       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    564    580       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01463}.
FT   TOPO_DOM    581    585       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    586    605       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01463}.
FT   TOPO_DOM    606    615       Cytoplasmic. {ECO:0000255}.
SQ   SEQUENCE   615 AA;  66632 MW;  1099E6A9CC988EBE CRC64;
     MLNRYPLWKY VMLIVVIVIG LLYALPNLFG EDPAVQITGA RGVAASEQTL IQVQKTLQEE
     KITAKSVALE EGAILARFDS TDTQLRAREA LMGVMGDKYV VALNLAPATP RWLAAIHAEP
     MKLGLDLRGG VHFLMEVDMD TALGKLQEQN IDSLRSDLRE KGIPYTTVRK ENNYGLSITF
     RDAKARDEAI AYLSKRHPDL VISSQGSNQL RAVMSDARLS EAREYAVQQN INILRNRVNQ
     LGVAEPVVQR QGADRIVVEL PGIQDTARAK EILGATATLE FRLVNTNVDQ AAAASGRVPG
     DSEVKQTREG QPVVLYKRVI LTGDHITDST SSQDEYNQPQ VNISLDSAGG NIMSNFTKDN
     IGKPMATLFV EYKDSGKKDA NGRAVLVKQE EVINIANIQS RLGNSFRITG INNPNEARQL
     SLLLRAGALI APIQIVEERT IGPTLGMQNI EQGLEACLAG LLVSILFMII FYKKFGLIAT
     SALIANLILI VGIMSLLPGA TLSMPGIAGI VLTLAVAVDA NVLINERIKE ELSNGRTVQQ
     AIDEGYRGAF SSIFDANITT LIKVIILYAV GTGAIKGFAI TTGIGVATSM FTAIVGTRAI
     VNLLYGGKRV KKLSI
//

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