(data stored in ACNUC7421 zone)

SWISSPROT: TSX_ECO57

ID   TSX_ECO57               Reviewed;         294 AA.
AC   P0A928; P22786;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   05-JUL-2017, entry version 74.
DE   RecName: Full=Nucleoside-specific channel-forming protein tsx;
DE   Flags: Precursor;
GN   Name=tsx; OrderedLocusNames=Z0512, ECs0464;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Functions as substrate-specific channel for nucleosides
CC       and deoxynucleosides. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
DR   EMBL; AE005174; AAG54760.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33887.1; -; Genomic_DNA.
DR   PIR; H90686; H90686.
DR   RefSeq; NP_308491.1; NC_002695.1.
DR   RefSeq; WP_001295328.1; NZ_MWVM01000009.1.
DR   ProteinModelPortal; P0A928; -.
DR   SMR; P0A928; -.
DR   STRING; 155864.Z0512; -.
DR   PRIDE; P0A928; -.
DR   EnsemblBacteria; AAG54760; AAG54760; Z0512.
DR   EnsemblBacteria; BAB33887; BAB33887; BAB33887.
DR   GeneID; 914566; -.
DR   KEGG; ece:Z0512; -.
DR   KEGG; ecs:ECs0464; -.
DR   PATRIC; fig|386585.9.peg.564; -.
DR   eggNOG; ENOG4105DRB; Bacteria.
DR   eggNOG; COG3248; LUCA.
DR   HOGENOM; HOG000273630; -.
DR   KO; K05517; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.230.20; -; 1.
DR   InterPro; IPR003055; Channel_Tsx.
DR   InterPro; IPR018013; Channel_Tsx-like.
DR   Pfam; PF03502; Channel_Tsx; 1.
DR   PRINTS; PR01277; CHANNELTSX.
DR   SUPFAM; SSF111364; SSF111364; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0A928.
DR   SWISS-2DPAGE; P0A928.
KW   Cell outer membrane; Complete proteome; Ion transport; Membrane;
KW   Porin; Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL        1     22       {ECO:0000255}.
FT   CHAIN        23    294       Nucleoside-specific channel-forming
FT                                protein tsx.
FT                                /FTId=PRO_0000025191.
SQ   SEQUENCE   294 AA;  33589 MW;  AB801DC563552A5C CRC64;
     MKKTLLAAGA VLALSSSFTV NAAENDKPQY LSDWWHQSVN VVGSYHTRFG PQIRNDTYLE
     YEAFAKKDWF DFYGYADAPV FFGGNSDAKG IWNHGSPLFM EIEPRFSIDK LTNTDLSFGP
     FKEWYFANNY IYDMGRNKDG RQSTWYMGLG TDIDTGLPMS LSMNVYAKYQ WQNYGAANEN
     EWDGYRFKIK YFVPITDLWG GQLSYIGFTN FDWGSDLGDD SGNAINGIKT RTNNSIASSH
     ILALNYDHWH YSVVARYWHD GGQWNDDAEL NFGNGNFNVR STGWGGYLVV GYNF
//

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