(data stored in ACNUC7421 zone)

SWISSPROT: NRDR_ECO57

ID   NRDR_ECO57              Reviewed;         149 AA.
AC   P0A8D2; P25538;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   05-JUL-2017, entry version 80.
DE   RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN   Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440}; Synonyms=ybaD;
GN   OrderedLocusNames=Z0514, ECs0466;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Negatively regulates transcription of bacterial
CC       ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC       boxes. {ECO:0000255|HAMAP-Rule:MF_00440}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00440};
CC       Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC   -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00440}.
DR   EMBL; AE005174; AAG54762.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33889.1; -; Genomic_DNA.
DR   PIR; B90687; B90687.
DR   PIR; F85537; F85537.
DR   RefSeq; NP_308493.1; NC_002695.1.
DR   RefSeq; WP_000543535.1; NZ_MWVM01000009.1.
DR   ProteinModelPortal; P0A8D2; -.
DR   MINT; MINT-1276162; -.
DR   STRING; 155864.Z0514; -.
DR   PRIDE; P0A8D2; -.
DR   EnsemblBacteria; AAG54762; AAG54762; Z0514.
DR   EnsemblBacteria; BAB33889; BAB33889; BAB33889.
DR   GeneID; 914568; -.
DR   KEGG; ece:Z0514; -.
DR   KEGG; ecs:ECs0466; -.
DR   PATRIC; fig|386585.9.peg.566; -.
DR   eggNOG; ENOG4108Z11; Bacteria.
DR   eggNOG; COG1327; LUCA.
DR   HOGENOM; HOG000097653; -.
DR   KO; K07738; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   HAMAP; MF_00440; NrdR; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR003796; RNR_NrdR-like.
DR   PANTHER; PTHR30455:SF3; PTHR30455:SF3; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   TIGRFAMs; TIGR00244; TIGR00244; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0A8D2.
DR   SWISS-2DPAGE; P0A8D2.
KW   ATP-binding; Complete proteome; DNA-binding; Metal-binding;
KW   Nucleotide-binding; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    149       Transcriptional repressor NrdR.
FT                                /FTId=PRO_0000182297.
FT   DOMAIN       49    139       ATP-cone. {ECO:0000255|HAMAP-
FT                                Rule:MF_00440}.
FT   ZN_FING       3     34       {ECO:0000255|HAMAP-Rule:MF_00440}.
SQ   SEQUENCE   149 AA;  17229 MW;  EFF99DD555EF2D26 CRC64;
     MHCPFCFAVD TKVIDSRLVG EGSSVRRRRQ CLVCNERFTT FEVAELVMPR VVKSNDVREP
     FNEEKLRSGM LRALEKRPVS SDDVEMAINH IKSQLRATGE REVPSKMIGN LVMEQLKKLD
     KVAYIRFASV YRSFEDIKEF GEEIARLED
//

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