(data stored in ACNUC7421 zone)

SWISSPROT: CYOE_ECO57

ID   CYOE_ECO57              Reviewed;         296 AA.
AC   P0AEA7; P18404; P77115;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   05-JUL-2017, entry version 82.
DE   RecName: Full=Protoheme IX farnesyltransferase {ECO:0000255|HAMAP-Rule:MF_00154};
DE            EC=2.5.1.- {ECO:0000255|HAMAP-Rule:MF_00154};
DE   AltName: Full=Heme B farnesyltransferase {ECO:0000255|HAMAP-Rule:MF_00154};
DE   AltName: Full=Heme O synthase {ECO:0000255|HAMAP-Rule:MF_00154};
GN   Name=cyoE {ECO:0000255|HAMAP-Rule:MF_00154};
GN   OrderedLocusNames=Z0531, ECs0482;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution
CC       of the vinyl group on carbon 2 of heme B porphyrin ring with a
CC       hydroxyethyl farnesyl side group. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; heme O
CC       biosynthesis; heme O from protoheme: step 1/1. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00154}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
CC       according to the Fischer nomenclature. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       Protoheme IX farnesyltransferase subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
DR   EMBL; AE005174; AAG54778.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33905.1; -; Genomic_DNA.
DR   PIR; B90689; B90689.
DR   PIR; F85539; F85539.
DR   RefSeq; NP_308509.1; NC_002695.1.
DR   RefSeq; WP_000971336.1; NZ_MWVM01000009.1.
DR   ProteinModelPortal; P0AEA7; -.
DR   STRING; 155864.Z0531; -.
DR   EnsemblBacteria; AAG54778; AAG54778; Z0531.
DR   EnsemblBacteria; BAB33905; BAB33905; BAB33905.
DR   GeneID; 914584; -.
DR   KEGG; ece:Z0531; -.
DR   KEGG; ecs:ECs0482; -.
DR   PATRIC; fig|386585.9.peg.583; -.
DR   eggNOG; ENOG4105F1R; Bacteria.
DR   eggNOG; COG0109; LUCA.
DR   HOGENOM; HOG000237290; -.
DR   KO; K02301; -.
DR   UniPathway; UPA00834; UER00712.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:InterPro.
DR   GO; GO:0048034; P:heme O biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd13957; PT_UbiA_Cox10; 1.
DR   HAMAP; MF_00154; CyoE_CtaB; 1.
DR   InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   InterPro; IPR030470; UbiA_prenylTrfase_CS.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
DR   PROSITE; PS00943; UBIA; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0AEA7.
DR   SWISS-2DPAGE; P0AEA7.
KW   Cell inner membrane; Cell membrane; Complete proteome;
KW   Heme biosynthesis; Membrane; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    296       Protoheme IX farnesyltransferase.
FT                                /FTId=PRO_0000162896.
FT   TOPO_DOM      1      9       Cytoplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM     10     28       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TOPO_DOM     29     37       Periplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM     38     56       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TOPO_DOM     57     78       Cytoplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM     79     97       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TOPO_DOM     98    107       Periplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    108    126       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TOPO_DOM    127    197       Cytoplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    198    216       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TOPO_DOM    217    228       Periplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    229    247       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TOPO_DOM    248    268       Cytoplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    269    287       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TOPO_DOM    288    296       Periplasmic. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
SQ   SEQUENCE   296 AA;  32248 MW;  D3AFC612ECFB450E CRC64;
     MMFKQYLQVT KPGIIFGNLI SVIGGFLLAS KGSIDYPLFI YTLVGVSLVV ASGCVFNNYI
     DRDIDRKMER TKNRVLVKGL ISPAVSLVYA TLLGIAGFML LWFGANPLAC WLGVMGFVVY
     VGVYSLYMKR HSVYGTLIGS LSGAAPPVIG YCAVTGEFDS GAAILLAIFS LWQMPHSYAI
     AIFRFKDYQA ANIPVLPVVK GISVAKNHIT LYIIAFAVAT LMLSLGGYAG YKYLVVAAAV
     SVWWLGMALR GYKVADDRIW ARKLFGFSII AITALSVMMS VDFMVPDSHT LLAAVW
//

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