(data stored in ACNUC7421 zone)

SWISSPROT: QUEC_ECO57

ID   QUEC_ECO57              Reviewed;         231 AA.
AC   Q8XE52; Q7AGZ7;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 100.
DE   RecName: Full=7-cyano-7-deazaguanine synthase {ECO:0000255|HAMAP-Rule:MF_01633};
DE            EC=6.3.4.20 {ECO:0000255|HAMAP-Rule:MF_01633};
DE   AltName: Full=7-cyano-7-carbaguanine synthase {ECO:0000255|HAMAP-Rule:MF_01633};
DE   AltName: Full=PreQ(0) synthase {ECO:0000255|HAMAP-Rule:MF_01633};
DE   AltName: Full=Queuosine biosynthesis protein QueC {ECO:0000255|HAMAP-Rule:MF_01633};
GN   Name=queC {ECO:0000255|HAMAP-Rule:MF_01633};
GN   OrderedLocusNames=Z0551, ECs0498;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Catalyzes the ATP-dependent conversion of 7-carboxy-7-
CC       deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
CC       {ECO:0000255|HAMAP-Rule:MF_01633}.
CC   -!- CATALYTIC ACTIVITY: 7-carboxy-7-carbaguanine + NH(3) + ATP = 7-
CC       cyano-7-carbaguanine + ADP + phosphate + H(2)O.
CC       {ECO:0000255|HAMAP-Rule:MF_01633}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01633};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_01633};
CC   -!- PATHWAY: Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01633}.
CC   -!- SIMILARITY: Belongs to the QueC family. {ECO:0000255|HAMAP-
CC       Rule:MF_01633}.
DR   EMBL; AE005174; AAG54794.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33921.1; -; Genomic_DNA.
DR   PIR; B90691; B90691.
DR   PIR; F85541; F85541.
DR   RefSeq; NP_308525.1; NC_002695.1.
DR   RefSeq; WP_000817243.1; NZ_MWVM01000009.1.
DR   ProteinModelPortal; Q8XE52; -.
DR   SMR; Q8XE52; -.
DR   STRING; 155864.Z0551; -.
DR   EnsemblBacteria; AAG54794; AAG54794; Z0551.
DR   EnsemblBacteria; BAB33921; BAB33921; BAB33921.
DR   GeneID; 914600; -.
DR   KEGG; ece:Z0551; -.
DR   KEGG; ecs:ECs0498; -.
DR   PATRIC; fig|386585.9.peg.601; -.
DR   eggNOG; ENOG4105FD2; Bacteria.
DR   eggNOG; COG0603; LUCA.
DR   HOGENOM; HOG000110563; -.
DR   KO; K06920; -.
DR   UniPathway; UPA00391; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008616; P:queuosine biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd01995; ExsB; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_01633; QueC; 1.
DR   InterPro; IPR018317; QueC.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR42914; PTHR42914; 1.
DR   Pfam; PF06508; QueC; 1.
DR   PIRSF; PIRSF006293; ExsB; 1.
DR   TIGRFAMs; TIGR00364; TIGR00364; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8XE52.
DR   SWISS-2DPAGE; Q8XE52.
KW   ATP-binding; Complete proteome; Ligase; Metal-binding;
KW   Nucleotide-binding; Queuosine biosynthesis; Zinc.
FT   CHAIN         1    231       7-cyano-7-deazaguanine synthase.
FT                                /FTId=PRO_0000246841.
FT   NP_BIND       8     18       ATP. {ECO:0000255|HAMAP-Rule:MF_01633}.
FT   METAL       188    188       Zinc. {ECO:0000255|HAMAP-Rule:MF_01633}.
FT   METAL       197    197       Zinc. {ECO:0000255|HAMAP-Rule:MF_01633}.
FT   METAL       200    200       Zinc. {ECO:0000255|HAMAP-Rule:MF_01633}.
FT   METAL       203    203       Zinc. {ECO:0000255|HAMAP-Rule:MF_01633}.
SQ   SEQUENCE   231 AA;  25480 MW;  2C31DBB7281F592B CRC64;
     MKRAVVVFSG GQDSTTCLVQ ALQQYDEVHC VTFDYGQRHR AEIDVARELA LKLGARAHKV
     LDVTLLNELA VSSLTRDSIP VPDYEPEADG IPNTFVPGRN ILFLTLAAIY AYQVKAEAVI
     TGVCETDFSG YPDCRDEFVK VLNHAVSLGM AKDIRFETPL MWIDKAETWA LADYYGKLDL
     VRNETLTCYN GIKGDGCGHC AACNLRANGL NHYLADKPTV MAAMKQKTGL K
//

If you have problems or comments...

PBIL Back to PBIL home page