(data stored in ACNUC7421 zone)

SWISSPROT: MDLB_ECO57

ID   MDLB_ECO57              Reviewed;         593 AA.
AC   P0AAG7; P30751; P75706; P77117;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   05-JUL-2017, entry version 86.
DE   RecName: Full=Multidrug resistance-like ATP-binding protein MdlB;
DE            EC=3.6.3.44;
GN   Name=mdlB; OrderedLocusNames=Z0559, ECs0503;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O + xenobiotic(In) = ADP + phosphate
CC       + xenobiotic(Out).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Drug
CC       exporter-2 (TC 3.A.1.117) family. {ECO:0000305}.
DR   EMBL; AE005174; AAG54799.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33926.1; -; Genomic_DNA.
DR   PIR; C85542; C85542.
DR   PIR; G90691; G90691.
DR   RefSeq; NP_308530.1; NC_002695.1.
DR   RefSeq; WP_001256201.1; NZ_MWVM01000009.1.
DR   ProteinModelPortal; P0AAG7; -.
DR   SMR; P0AAG7; -.
DR   STRING; 155864.Z0559; -.
DR   EnsemblBacteria; AAG54799; AAG54799; Z0559.
DR   EnsemblBacteria; BAB33926; BAB33926; BAB33926.
DR   GeneID; 914605; -.
DR   KEGG; ece:Z0559; -.
DR   KEGG; ecs:ECs0503; -.
DR   PATRIC; fig|386585.9.peg.607; -.
DR   eggNOG; ENOG4105BZ1; Bacteria.
DR   eggNOG; COG1132; LUCA.
DR   KO; K18890; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008559; F:xenobiotic-transporting ATPase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR003439; ABC_transporter-like.
DR   InterPro; IPR017871; ABC_transporter_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00664; ABC_membrane; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF90123; SSF90123; 1.
DR   PROSITE; PS50929; ABC_TM1F; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0AAG7.
DR   SWISS-2DPAGE; P0AAG7.
KW   ATP-binding; Cell inner membrane; Cell membrane; Complete proteome;
KW   Hydrolase; Membrane; Nucleotide-binding; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN         1    593       Multidrug resistance-like ATP-binding
FT                                protein MdlB.
FT                                /FTId=PRO_0000092497.
FT   TOPO_DOM      1     25       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     26     46       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM     47     62       Periplasmic. {ECO:0000255}.
FT   TRANSMEM     63     83       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM     84    140       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    141    161       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM    162    164       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    165    185       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM    186    254       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    255    275       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM    276    278       Periplasmic. {ECO:0000255}.
FT   TRANSMEM    279    299       Helical. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00441}.
FT   TOPO_DOM    300    593       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       25    310       ABC transmembrane type-1.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00441}.
FT   DOMAIN      341    574       ABC transporter. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00434}.
FT   NP_BIND     374    381       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00434}.
SQ   SEQUENCE   593 AA;  65222 MW;  CF1EE70009EB05D8 CRC64;
     MRSFSQLWPT LKRLLAYGSP WRKPLGIAVL MMWVAAAAEV SGPLLISYFI DNMVAKNNLP
     LKVVAGLAAA YVGLQLFAAG LHYAQSLLFN RAAVGVVQQL RTDVMDAALR QPLSEFDTQP
     VGQVISRVTN DTEVIRDLYV TVVATVLRSA ALVGAMLVAM FSLDWRMALV AIMIFPVVLV
     VMVIYQRYST PIVRRVRAYL ADINDGFNEI INGMSVIQQF RQQARFGERM GEASRSHYMA
     RMQTLRLDGF LLRPLLSLFS SLILCGLLML FGFSASGTIE VGVLYAFISY LGRLNEPLIE
     LTTQQAMLQQ AVVAGERVFE LMDGPRQQYG NDDRPLQSGT IEVDNVSFAY RDDNLVLKNI
     NLSVPSRNFV ALVGHTGSGK STLASLLMGY YPLTEGEIRL DGRPLSSLSH SALRQGVAMV
     QQDPVVLADT FLANVTLGRD ISEERVWQAL ETVQLAELAR SMSDGIYTPL GEQGNNLSVG
     QKQLLALARV LVETPQILIL DEATASIDSG TEQAIQHALA AVREHTTLVV IAHRLSTIVD
     ADTILVLHRG QAVEQGTHQQ LLAAQGRYWQ MYQLQLAGEE LAASVREEES LSA
//

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