(data stored in ACNUC7421 zone)

SWISSPROT: HHA_ECO57

ID   HHA_ECO57               Reviewed;          72 AA.
AC   P0ACE5; P23870; P77120;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   05-JUL-2017, entry version 70.
DE   RecName: Full=Hemolysin expression-modulating protein Hha;
GN   Name=hha; OrderedLocusNames=Z0573, ECs0513;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Down-regulates hemolysin expression, in complex with H-
CC       NS, and can also stimulate transposition events in vivo. Modifies
CC       the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase
CC       the number of genes DNA bound by H-NS/StpA and may also modulate
CC       the oligomerization of the H-NS/StpA-complex. Binds DNA and
CC       influences DNA topology in response to environmental stimuli.
CC       Decreases biofilm formation (By similarity).
CC       {ECO:0000250|UniProtKB:P0ACE3}.
CC   -!- SUBUNIT: Forms a heterotrimeric complex with the H-NS dimer.
CC       {ECO:0000250|UniProtKB:P0ACE3}.
CC   -!- SIMILARITY: Belongs to the Hha/YmoA/Cnu family. {ECO:0000305}.
DR   EMBL; AE005174; AAG54809.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33936.1; -; Genomic_DNA.
DR   PIR; A99693; A99693.
DR   PIR; E85543; E85543.
DR   RefSeq; NP_308540.1; NC_002695.1.
DR   RefSeq; WP_001291435.1; NZ_MWVM01000009.1.
DR   ProteinModelPortal; P0ACE5; -.
DR   SMR; P0ACE5; -.
DR   STRING; 155864.Z0573; -.
DR   EnsemblBacteria; AAG54809; AAG54809; Z0573.
DR   EnsemblBacteria; BAB33936; BAB33936; BAB33936.
DR   GeneID; 914617; -.
DR   KEGG; ece:Z0573; -.
DR   KEGG; ecs:ECs0513; -.
DR   PATRIC; fig|386585.9.peg.618; -.
DR   eggNOG; ENOG4105KF5; Bacteria.
DR   eggNOG; ENOG4111U15; LUCA.
DR   HOGENOM; HOG000219358; -.
DR   KO; K05839; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:1900191; P:negative regulation of single-species biofilm formation; IMP:CACAO.
DR   GO; GO:2000147; P:positive regulation of cell motility; IMP:CACAO.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1280.40; -; 1.
DR   InterPro; IPR007985; Hemolysn_expr_modulating_HHA.
DR   Pfam; PF05321; HHA; 1.
DR   SUPFAM; SSF68989; SSF68989; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0ACE5.
DR   SWISS-2DPAGE; P0ACE5.
KW   Complete proteome; DNA-binding; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN         1     72       Hemolysin expression-modulating protein
FT                                Hha.
FT                                /FTId=PRO_0000201728.
FT   SITE         25     25       Interacts with H-NS. {ECO:0000250}.
FT   SITE         48     48       Interacts with H-NS. {ECO:0000250}.
SQ   SEQUENCE   72 AA;  8628 MW;  A77211B87CF0134A CRC64;
     MSEKPLTKTD YLMRLRRCQT IDTLERVIEK NKYELSDNEL AVFYSAADHR LAELTMNKLY
     DKIPSSVWKF IR
//

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