(data stored in ACNUC7421 zone)

SWISSPROT: Q8XD55_ECO57

ID   Q8XD55_ECO57            Unreviewed;      1049 AA.
AC   Q8XD55; Q7AGY9;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   30-AUG-2017, entry version 97.
DE   RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN   Name=acrB {ECO:0000313|EMBL:AAG54811.1};
GN   OrderedLocusNames=ECs0515 {ECO:0000313|EMBL:BAB33938.1}, Z0576
GN   {ECO:0000313|EMBL:AAG54811.1};
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334 {ECO:0000313|Proteomes:UP000002519};
RN   [1] {ECO:0000313|EMBL:BAB33938.1, ECO:0000313|Proteomes:UP000000558}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC
RC   {ECO:0000313|Proteomes:UP000000558}, and Sakai
RC   {ECO:0000313|EMBL:BAB33938.1};
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [2] {ECO:0000313|EMBL:AAG54811.1, ECO:0000313|Proteomes:UP000002519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EDL933 {ECO:0000313|EMBL:AAG54811.1}, and O157:H7 / EDL933 /
RC   ATCC 700927 / EHEC {ECO:0000313|Proteomes:UP000002519};
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G.III., Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU364070}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU364070}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division
CC       (RND) (TC 2.A.6) family. {ECO:0000256|RuleBase:RU364070,
CC       ECO:0000256|SAAS:SAAS00693190}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU364070}.
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DR   EMBL; AE005174; AAG54811.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33938.1; -; Genomic_DNA.
DR   PIR; C90693; C90693.
DR   PIR; G85543; G85543.
DR   RefSeq; NP_308542.1; NC_002695.1.
DR   RefSeq; WP_001132452.1; NZ_MWVM01000009.1.
DR   STRING; 155864.Z0576; -.
DR   EnsemblBacteria; AAG54811; AAG54811; Z0576.
DR   EnsemblBacteria; BAB33938; BAB33938; BAB33938.
DR   GeneID; 914619; -.
DR   KEGG; ece:Z0576; -.
DR   KEGG; ecs:ECs0515; -.
DR   PATRIC; fig|386585.9.peg.620; -.
DR   eggNOG; ENOG4105BZS; Bacteria.
DR   eggNOG; COG0841; LUCA.
DR   HOGENOM; HOG000158129; -.
DR   KO; K18138; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005215; F:transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.2090.10; -; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004764; HAE1.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
DR   TIGRFAMs; TIGR00915; 2A0602; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8XD55.
DR   SWISS-2DPAGE; Q8XD55.
KW   Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW   Cell membrane {ECO:0000256|RuleBase:RU364070};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000558,
KW   ECO:0000313|Proteomes:UP000002519};
KW   Membrane {ECO:0000256|RuleBase:RU364070};
KW   Transmembrane {ECO:0000256|RuleBase:RU364070};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU364070};
KW   Transport {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM     12     32       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    340    359       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    366    390       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    437    458       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    470    493       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    541    557       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    875    892       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    899    919       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    925    946       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM    975    995       Helical. {ECO:0000256|RuleBase:RU364070}.
FT   TRANSMEM   1007   1029       Helical. {ECO:0000256|RuleBase:RU364070}.
SQ   SEQUENCE   1049 AA;  113615 MW;  B42F053898194534 CRC64;
     MPNFFIDRPI FAWVIAIIIM LAGGLAILKL PVAQYPTIAP PAVTISASYP GADAKTVQDT
     VTQVIEQNMN GIDNLMYMSS NSDSTGTVQI TLTFESGTDA DIAQVQVQNK LQLAMPLLPQ
     EVQQQGVSIE KSSSSFLMVV GVINTDGTMT QEDISDYVAA NMKDAISRTS GVGDVQLFGS
     QYAMRIWMNP NELNKFQLTP VDVITAIKAQ NAQVAAGQLG GTPPVKGQQL NASIIAQTRL
     TSTEEFGKIL LKVNQDGSRV LLRDVAKIEL GGENYDIIAE FNGQPASGLG IKLATGANAL
     DTAAAIRAEL AKMEPFFPSG LKIVYPYDTT PFVKISIHEV VKTLVEAIIL VFLVMYLFLQ
     NFRATLIPTI AVPVVLLGTF AVLAAFGFSI NTLTMFGMVL AIGLLVDDAI VVVENVERVM
     AEEGLPPKEA TRKSMGQIQG ALVGIAMVLS AVFVPMAFFG GSTGAIYRQF SITIVSAMAL
     SVLVALILTP ALCATMLKPI AKGDHGEGKK GFFGWFNRMF EKSTHHYTDS VGGILRSTGR
     YLVLYLIIVV GMAYLFVRLP SSFLPDEDQG VFMTMVQLPA GATQERTQKV LNEVTHYYLT
     KEKNNVESVF AVNGFGFAGR GQNTGIAFVS LKDWADRPGE ENKVEAITMR ATRAFSQIKD
     AMVFAFNLPA IVELGTATGF DFELIDQAGL GHEKLTQARN QLLAEAAKHP DMLTSVRPNG
     LEDTPQFKID IDQEKAQALG VSINDINTTL GAAWGGSYVN DFIDRGRVKK VYVMSEAKYR
     MLPDDIGDWY VRAADGQMVP FSAFSSSRWE YGSPRLERYN GLPSMEILGQ AAPGKSTGEA
     MELMEQLASK LPTGVGYDWT GMSYQERLSG NQAPSLYAIS LIVVFLCLAA LYESWSIPFS
     VMLVVPLGVI GALLAATFRG LTNDVYFQVG LLTTIGLSAK NAILIVEFAK DLMDKEGKGL
     IEATLDAVRM RLRPILMTSL AFILGVMPLV ISTGAGSGAQ NAVGTGVMGG MVTATVLAIF
     FVPVFFVVVR RRFSRKNEDI EHNHTVDHH
//

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