(data stored in ACNUC7421 zone)

SWISSPROT: CUER_ECO57

ID   CUER_ECO57              Reviewed;         135 AA.
AC   Q8XD09; Q8KY47;
DT   03-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 107.
DE   RecName: Full=HTH-type transcriptional regulator CueR;
DE   AltName: Full=Copper efflux regulator;
DE   AltName: Full=Copper export regulator;
GN   Name=cueR; OrderedLocusNames=Z0636, ECs0545;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-135.
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=12147073; DOI=10.1046/j.1365-2672.2002.01684.x;
RA   Perelle S., Fach P., Dilasser F., Grout J.;
RT   "A PCR test for detecting Escherichia coli O157:H7 based on the
RT   identification of the small inserted locus (SILO157).";
RL   J. Appl. Microbiol. 93:250-260(2002).
CC   -!- FUNCTION: Regulates the transcription of the copA and cueO genes.
CC       It detects cytoplasmic copper stress and activates transcription
CC       in response to increasing copper concentrations (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- DOMAIN: It contains a N-terminal DNA binding region and a C-
CC       terminal metal binding region. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG54841.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; AE005174; AAG54841.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB33968.1; -; Genomic_DNA.
DR   EMBL; AF288452; AAN02438.1; -; Genomic_DNA.
DR   PIR; A90697; A90697.
DR   PIR; E85547; E85547.
DR   RefSeq; NP_308572.1; NC_002695.1.
DR   RefSeq; WP_001026752.1; NZ_MWVM01000009.1.
DR   ProteinModelPortal; Q8XD09; -.
DR   SMR; Q8XD09; -.
DR   STRING; 155864.Z0636; -.
DR   PRIDE; Q8XD09; -.
DR   EnsemblBacteria; AAG54841; AAG54841; Z0636.
DR   EnsemblBacteria; BAB33968; BAB33968; BAB33968.
DR   GeneID; 915192; -.
DR   KEGG; ece:Z0636; -.
DR   KEGG; ecs:ECs0545; -.
DR   PATRIC; fig|386585.9.peg.652; -.
DR   eggNOG; COG0789; LUCA.
DR   HOGENOM; HOG000266076; -.
DR   KO; K11923; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   CDD; cd01108; HTH_CueR; 1.
DR   InterPro; IPR011789; CueR.
DR   InterPro; IPR009061; DNA-bd_dom_put.
DR   InterPro; IPR000551; MerR-type_HTH_dom.
DR   Pfam; PF13411; MerR_1; 1.
DR   PRINTS; PR00040; HTHMERR.
DR   SMART; SM00422; HTH_MERR; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   TIGRFAMs; TIGR02044; CueR; 1.
DR   PROSITE; PS00552; HTH_MERR_1; 1.
DR   PROSITE; PS50937; HTH_MERR_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8XD09.
DR   SWISS-2DPAGE; Q8XD09.
KW   Activator; Complete proteome; Copper; Cytoplasm; DNA-binding;
KW   Metal-binding; Transcription; Transcription regulation.
FT   CHAIN         1    135       HTH-type transcriptional regulator CueR.
FT                                /FTId=PRO_0000098113.
FT   DOMAIN        1     69       HTH merR-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00254}.
FT   DNA_BIND      4     23       H-T-H motif. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00254}.
FT   METAL       112    112       Copper(1+). {ECO:0000250}.
FT   METAL       120    120       Copper(1+). {ECO:0000250}.
SQ   SEQUENCE   135 AA;  15234 MW;  ADA0D919E3140862 CRC64;
     MNISDVAKIT GLTSKAIRFY EEKGLVTPPM RSENGYRTYT QQHLNELTLL RQARQVGFNL
     EESGELVNLF NDPQRHSADV KRRTLEKVAE IERHIEELQS MRNQLLALAN ACPGDDSADC
     PIIENLSGCC HHRAG
//

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