(data stored in ACNUC7421 zone)

SWISSPROT: PURE_ECO57

ID   PURE_ECO57              Reviewed;         169 AA.
AC   P0AG19; P09028;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   05-JUL-2017, entry version 81.
DE   RecName: Full=N5-carboxyaminoimidazole ribonucleotide mutase {ECO:0000255|HAMAP-Rule:MF_01929};
DE            Short=N5-CAIR mutase {ECO:0000255|HAMAP-Rule:MF_01929};
DE            EC=5.4.99.18 {ECO:0000255|HAMAP-Rule:MF_01929};
DE   AltName: Full=5-(carboxyamino)imidazole ribonucleotide mutase {ECO:0000255|HAMAP-Rule:MF_01929};
GN   Name=purE {ECO:0000255|HAMAP-Rule:MF_01929};
GN   OrderedLocusNames=Z0678, ECs0585;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Catalyzes the conversion of N5-carboxyaminoimidazole
CC       ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole
CC       ribonucleotide (CAIR). {ECO:0000255|HAMAP-Rule:MF_01929}.
CC   -!- CATALYTIC ACTIVITY: 5-carboxyamino-1-(5-phospho-D-
CC       ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-
CC       carboxylate. {ECO:0000255|HAMAP-Rule:MF_01929}.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.
CC       {ECO:0000255|HAMAP-Rule:MF_01929}.
CC   -!- SIMILARITY: Belongs to the AIR carboxylase family. Class I
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01929}.
DR   EMBL; AE005174; AAG54880.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34008.1; -; Genomic_DNA.
DR   PIR; A90702; A90702.
DR   PIR; D85552; D85552.
DR   RefSeq; NP_308612.1; NC_002695.1.
DR   RefSeq; WP_001295318.1; NZ_MWVM01000032.1.
DR   ProteinModelPortal; P0AG19; -.
DR   SMR; P0AG19; -.
DR   STRING; 155864.Z0678; -.
DR   PRIDE; P0AG19; -.
DR   EnsemblBacteria; AAG54880; AAG54880; Z0678.
DR   EnsemblBacteria; BAB34008; BAB34008; BAB34008.
DR   GeneID; 916940; -.
DR   KEGG; ece:Z0678; -.
DR   KEGG; ecs:ECs0585; -.
DR   PATRIC; fig|386585.9.peg.692; -.
DR   eggNOG; ENOG4108UM6; Bacteria.
DR   eggNOG; COG0041; LUCA.
DR   HOGENOM; HOG000034140; -.
DR   KO; K01588; -.
DR   UniPathway; UPA00074; UER00943.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0034023; F:5-(carboxyamino)imidazole ribonucleotide mutase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.7700; -; 1.
DR   HAMAP; MF_01929; PurE_classI; 1.
DR   InterPro; IPR033747; PurE_ClassI.
DR   InterPro; IPR000031; PurE_dom.
DR   InterPro; IPR024694; PurE_prokaryotes.
DR   Pfam; PF00731; AIRC; 1.
DR   PIRSF; PIRSF001338; AIR_carboxylase; 1.
DR   SMART; SM01001; AIRC; 1.
DR   SUPFAM; SSF52255; SSF52255; 1.
DR   TIGRFAMs; TIGR01162; purE; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0AG19.
DR   SWISS-2DPAGE; P0AG19.
KW   Complete proteome; Isomerase; Purine biosynthesis.
FT   INIT_MET      1      1       Removed. {ECO:0000250}.
FT   CHAIN         2    169       N5-carboxyaminoimidazole ribonucleotide
FT                                mutase.
FT                                /FTId=PRO_0000074974.
FT   BINDING      16     16       Substrate. {ECO:0000255|HAMAP-
FT                                Rule:MF_01929}.
FT   BINDING      19     19       Substrate. {ECO:0000255|HAMAP-
FT                                Rule:MF_01929}.
FT   BINDING      46     46       Substrate. {ECO:0000255|HAMAP-
FT                                Rule:MF_01929}.
SQ   SEQUENCE   169 AA;  17780 MW;  E8B745B8D86E7D0B CRC64;
     MSSRNNPARV AIVMGSKSDW ATMQFAAEIF EILNVPHHVE VVSAHRTPDK LFSFAESAEE
     NGYQVIIAGA GGAAHLPGMI AAKTLVPVLG VPVQSAALSG VDSLYSIVQM PRGIPVGTLA
     IGKAGAANAA LLAAQILATH DKELHQRLND WRKAQTDEVL ENPDPRGAA
//

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