(data stored in ACNUC7421 zone)

SWISSPROT: CUSR_ECO57

ID   CUSR_ECO57              Reviewed;         227 AA.
AC   P0AD00; P77380;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   30-AUG-2017, entry version 85.
DE   RecName: Full=Transcriptional regulatory protein CusR;
GN   Name=cusR; OrderedLocusNames=Z0709, ECs0609;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Member of the two-component regulatory system CusS/CusR.
CC       Activates the expression of cusCFBA in response to increasing
CC       levels of copper ions, and probably silver ions (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated by CusS. {ECO:0000250}.
DR   EMBL; AE005174; AAG54904.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34032.1; -; Genomic_DNA.
DR   PIR; A90705; A90705.
DR   PIR; D85555; D85555.
DR   RefSeq; NP_308636.1; NC_002695.1.
DR   RefSeq; WP_000770953.1; NZ_MWVM01000011.1.
DR   ProteinModelPortal; P0AD00; -.
DR   SMR; P0AD00; -.
DR   STRING; 155864.Z0709; -.
DR   EnsemblBacteria; AAG54904; AAG54904; Z0709.
DR   EnsemblBacteria; BAB34032; BAB34032; BAB34032.
DR   GeneID; 916967; -.
DR   KEGG; ece:Z0709; -.
DR   KEGG; ecs:ECs0609; -.
DR   PATRIC; fig|386585.9.peg.717; -.
DR   eggNOG; ENOG4105CK6; Bacteria.
DR   eggNOG; COG0745; LUCA.
DR   HOGENOM; HOG000034815; -.
DR   KO; K07665; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   CDD; cd00156; REC; 1.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR006291; PcoR.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   PANTHER; PTHR26402:SF684; PTHR26402:SF684; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   TIGRFAMs; TIGR01387; cztR_silR_copR; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0AD00.
DR   SWISS-2DPAGE; P0AD00.
KW   Activator; Complete proteome; Copper; Cytoplasm; DNA-binding;
KW   Phosphoprotein; Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN         1    227       Transcriptional regulatory protein CusR.
FT                                /FTId=PRO_0000081064.
FT   DOMAIN        2    116       Response regulatory.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00169}.
FT   DNA_BIND    125    223       OmpR/PhoB-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01091}.
FT   MOD_RES      51     51       4-aspartylphosphate.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00169}.
SQ   SEQUENCE   227 AA;  25395 MW;  5CE129597FAE43C0 CRC64;
     MKLLIVEDEK KTGEYLTKGL TEAGFVVDLA DNGLNGYHLA MTGDYDLIIL DIMLPDVNGW
     DIVRMLRSAN KGMPILLLTA LGTIEHRVKG LELGADDYLV KPFAFAELLA RVRTLLRRGA
     AVIIESQFQV ADLMVDLVSR KVTRSGTRIT LTSKEFTLLE FFLRHQGEVL PRSLIASQVW
     DMNFDSDTNA IDVAVKRLRG KIDNDFEPKL IQTVRGVGYM LEVPDGQ
//

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