(data stored in ACNUC7421 zone)

SWISSPROT: CUSF_ECO57

ID   CUSF_ECO57              Reviewed;         110 AA.
AC   Q8XBY2;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 78.
DE   RecName: Full=Cation efflux system protein CusF;
DE   Flags: Precursor;
GN   Name=cusF; OrderedLocusNames=Z0712, ECs0611;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Part of a cation efflux system that mediates resistance
CC       to copper and silver. Binds one copper per polypeptide (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The cus efflux system is composed of CusA, CusB, CusC and
CC       CusF. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- INDUCTION: Transcriptionally regulated by CusR in response to
CC       copper and silver ions. {ECO:0000305}.
DR   EMBL; AE005174; AAG54906.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34034.1; -; Genomic_DNA.
DR   PIR; C90705; C90705.
DR   PIR; F85555; F85555.
DR   RefSeq; NP_308638.1; NC_002695.1.
DR   RefSeq; WP_000709868.1; NZ_MWVM01000011.1.
DR   ProteinModelPortal; Q8XBY2; -.
DR   SMR; Q8XBY2; -.
DR   STRING; 155864.Z0712; -.
DR   EnsemblBacteria; AAG54906; AAG54906; Z0712.
DR   EnsemblBacteria; BAB34034; BAB34034; BAB34034.
DR   GeneID; 916969; -.
DR   KEGG; ece:Z0712; -.
DR   KEGG; ecs:ECs0611; -.
DR   PATRIC; fig|386585.9.peg.719; -.
DR   eggNOG; ENOG410624V; Bacteria.
DR   eggNOG; COG5569; LUCA.
DR   HOGENOM; HOG000126315; -.
DR   KO; K07810; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR021647; CusF_Ec.
DR   Pfam; PF11604; CusF_Ec; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8XBY2.
DR   SWISS-2DPAGE; Q8XBY2.
KW   Complete proteome; Copper; Metal-binding; Periplasm; Signal.
FT   SIGNAL        1     21       {ECO:0000250}.
FT   CHAIN        22    110       Cation efflux system protein CusF.
FT                                /FTId=PRO_0000021044.
SQ   SEQUENCE   110 AA;  12213 MW;  40D018A39E27DB56 CRC64;
     MKKALQVAMF SLFTVIGFNA QANEHHHETM SEAQPQVISA TGVVKGFDLE SKKITIHHDP
     IAAVNWPEMT MRFTITPQTK MSGIKTGDKV AFNFVQQGNL SLLQDIKVSQ
//

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