(data stored in ACNUC7421 zone)

SWISSPROT: CUSB_ECO57

ID   CUSB_ECO57              Reviewed;         407 AA.
AC   Q8XEH9;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   07-JUN-2017, entry version 78.
DE   RecName: Full=Cation efflux system protein CusB;
DE   Flags: Precursor;
GN   Name=cusB; OrderedLocusNames=Z0713, ECs0612;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Part of a cation efflux system that mediates resistance
CC       to copper and silver. {ECO:0000250}.
CC   -!- SUBUNIT: The cus efflux system is composed of CusA, CusB, CusC and
CC       CusF. {ECO:0000250}.
CC   -!- INDUCTION: Transcriptionally regulated by CusR in response to
CC       copper and silver ions. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP)
CC       (TC 8.A.1) family. {ECO:0000305}.
DR   EMBL; AE005174; AAG54907.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34035.1; -; Genomic_DNA.
DR   PIR; D90705; D90705.
DR   PIR; G85555; G85555.
DR   RefSeq; NP_308639.1; NC_002695.1.
DR   RefSeq; WP_000717112.1; NZ_LPWC02000002.1.
DR   ProteinModelPortal; Q8XEH9; -.
DR   SMR; Q8XEH9; -.
DR   STRING; 155864.Z0713; -.
DR   EnsemblBacteria; AAG54907; AAG54907; Z0713.
DR   EnsemblBacteria; BAB34035; BAB34035; BAB34035.
DR   GeneID; 916970; -.
DR   KEGG; ece:Z0713; -.
DR   KEGG; ecs:ECs0612; -.
DR   PATRIC; fig|386585.9.peg.720; -.
DR   eggNOG; ENOG4105EP1; Bacteria.
DR   eggNOG; ENOG410XPHF; LUCA.
DR   HOGENOM; HOG000126091; -.
DR   KO; K07798; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005215; F:transporter activity; IEA:InterPro.
DR   GO; GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR032317; HlyD_D23.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF00529; HlyD; 1.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8XEH9.
DR   SWISS-2DPAGE; Q8XEH9.
KW   Complete proteome; Copper; Copper transport; Ion transport; Signal;
KW   Transport.
FT   SIGNAL        1     28       {ECO:0000255}.
FT   CHAIN        29    407       Cation efflux system protein CusB.
FT                                /FTId=PRO_0000018691.
FT   CONFLICT    316    316       K -> Q (in Ref. 2; BAB34035).
FT                                {ECO:0000305}.
SQ   SEQUENCE   407 AA;  44323 MW;  B202DFABC28ABC97 CRC64;
     MKKIALIIGS MIAGGIISAA GFTWFAKAEP PAEKTSTAER KILFWYDPMY PNTRFDKPGK
     SPFMDMDLVP KYADEESSAS GVRIDPTQTQ NLGVKTATVT RGPLTFAQSF PANVSYNEYQ
     YAIVQARAAG FIDKVYPLTV GDKVQKGAPL LDLTIPDWVE AQSEYLLLRE TGGTATQTEG
     ILERLRLAGM PEADIRRLIA TQKIQTRFTL KAPIDGVITA FDLRAGMNIA KDNVVAKIQG
     MDPVWVTAAI PESIAWLVKD ASQFTLTVPA RPDKTLTIRK WTLLPGVDAA TRTLQLRLEV
     DNADEALKPG MNAWLKLNTA SEPMLLIPSQ ALIDTGSEQR VITVDADGRF VPKRVAVFQA
     SQGVTALRSG LAEGEKVVSS GLFLIDSEAN ISGALERMRS ESATHAH
//

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