(data stored in ACNUC7421 zone)

SWISSPROT: CUSA_ECO57

ID   CUSA_ECO57              Reviewed;        1045 AA.
AC   Q8XBY1;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 88.
DE   RecName: Full=Cation efflux system protein CusA;
GN   Name=cusA; OrderedLocusNames=Z0714, ECs0613;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Part of a cation efflux system that mediates resistance
CC       to copper and silver. {ECO:0000250}.
CC   -!- SUBUNIT: The cus efflux system is composed of CusA, CusB, CusC and
CC       CusF. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-
CC       pass membrane protein {ECO:0000305}.
CC   -!- INDUCTION: Transcriptionally regulated by CusR in response to
CC       copper and silver ions. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division
CC       (RND) (TC 2.A.6) family. {ECO:0000305}.
DR   EMBL; AE005174; AAG54908.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34036.1; -; Genomic_DNA.
DR   PIR; E90705; E90705.
DR   PIR; H85555; H85555.
DR   RefSeq; NP_308640.1; NC_002695.1.
DR   RefSeq; WP_000573920.1; NZ_MWVM01000011.1.
DR   ProteinModelPortal; Q8XBY1; -.
DR   SMR; Q8XBY1; -.
DR   STRING; 155864.Z0714; -.
DR   EnsemblBacteria; AAG54908; AAG54908; Z0714.
DR   EnsemblBacteria; BAB34036; BAB34036; BAB34036.
DR   GeneID; 916972; -.
DR   KEGG; ece:Z0714; -.
DR   KEGG; ecs:ECs0613; -.
DR   PATRIC; fig|386585.9.peg.721; -.
DR   eggNOG; ENOG4108IJF; Bacteria.
DR   eggNOG; COG3696; LUCA.
DR   HOGENOM; HOG000126202; -.
DR   KO; K07787; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004763; CzcA/CusA/SilA/NccA/HelA/CnrA.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
DR   TIGRFAMs; TIGR00914; 2A0601; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q8XBY1.
DR   SWISS-2DPAGE; Q8XBY1.
KW   Cell inner membrane; Cell membrane; Complete proteome; Copper;
KW   Copper transport; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN         1   1045       Cation efflux system protein CusA.
FT                                /FTId=PRO_0000161816.
FT   TRANSMEM     14     34       Helical. {ECO:0000255}.
FT   TRANSMEM    336    356       Helical. {ECO:0000255}.
FT   TRANSMEM    361    381       Helical. {ECO:0000255}.
FT   TRANSMEM    388    408       Helical. {ECO:0000255}.
FT   TRANSMEM    444    464       Helical. {ECO:0000255}.
FT   TRANSMEM    483    503       Helical. {ECO:0000255}.
FT   TRANSMEM    530    550       Helical. {ECO:0000255}.
FT   TRANSMEM    869    889       Helical. {ECO:0000255}.
FT   TRANSMEM    896    916       Helical. {ECO:0000255}.
FT   TRANSMEM    926    946       Helical. {ECO:0000255}.
FT   TRANSMEM    983   1003       Helical. {ECO:0000255}.
FT   TRANSMEM   1010   1030       Helical. {ECO:0000255}.
SQ   SEQUENCE   1045 AA;  114538 MW;  3DC0AAE0F8C5278D CRC64;
     MIEWIIRRSV ANRFLVLMGA LFLSIWGTWT IINTPVDALP DLSDVQVIIK TSYPGQAPQI
     VENQVTYPLT TTMLSVPGAK TVRGFSQFGD SYVYVIFEDG TDPYWARSRV LEYLNQVQGK
     LPAGVSAELG PDATGVGWIY EYALVDRSGK HDLADLRSLQ DWFLKYELKT IPDVAEVASV
     GGVVKEYQVV IDPQRLAQYG ISLAEVKSAL DASNQEAGGS SIELAEAEYM VRASGYLQTL
     DDFNHIVLKA SENGVPVYLR DVAKIQVGPE MRRGIAELNG EVVGGVVILR SGKNAREVIA
     AVKDKLETLK SSLPEGVEIV TTYDRSQLID RAIDNLSGKL LEEFIVVAVV CALFLWHVRS
     ALVAIISLPL GLCIAFIVMH FQGLNANIMS LGGIAIAVGA MVDAAIVMIE NAHKRLEEWQ
     HQHPDATLDN KTRWQVITNA SVEVGPALFI SLLIITLSFI PIFTLEGQEG RLFGPLAFTK
     TYAMAGAALL AIVVIPILMG YWIRGKIPPE SSNPLNRFLI RVYHPLLLKV LHWPKTTLLV
     AALSVLTVLW PLNKVGGEFL PQINEGDLLY MPSTLPGISA AEAASMLQKT DKLIMSVPEV
     ARVFGKTGKA ETATDSAPLE MVETTIQLKP QEQWRPGMTM DKIIEELDNT VRLPGLANLW
     VPPIRNRIDM LSTGIKSPIG IKVSGTVLAD IDAMAEQIEE VARTVPGVAS ALAERLEGGR
     YINVEINREK AARYGMTVAD VQLFVTSAVG GAMVGETVEG IARYPINLRY PQSWRDSPQA
     LRQLPILTPM KQQITLADVA DVKVSTGPSM LKTENARPTS WIYIDARDRD MVSVVHDLQK
     AIAEKVQLKP GTSVAFSGQF ELLERANHKL KLMVPMTLMI IFVLLYLAFR RVGEALLIIS
     SVPFALVGGI WLLWWMGFHL SVATGTGFIA LAGVAAEFGV VMLMYLRHAI EAEPSLNNPQ
     TFSEQKLDEA LHHGAVLRVR PKAMTVAVII AGLLPILWGT GAGSEVMSRI AAPMIGGMIT
     APLLSLFIIP AAYKLMWLHR HRVRK
//

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