(data stored in ACNUC7421 zone)

SWISSPROT: ENTD_ECO57

ID   ENTD_ECO57              Reviewed;         206 AA.
AC   P0A3B9; Q54153; Q8XBW8;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 2.
DT   05-JUL-2017, entry version 75.
DE   RecName: Full=Enterobactin synthase component D {ECO:0000250|UniProtKB:P19925};
DE   AltName: Full=4'-phosphopantetheinyl transferase EntD {ECO:0000250|UniProtKB:P19925};
DE            EC=2.7.8.- {ECO:0000250|UniProtKB:P19925};
DE   AltName: Full=Enterochelin synthase D {ECO:0000250|UniProtKB:P19925};
GN   Name=entD {ECO:0000250|UniProtKB:P19925};
GN   OrderedLocusNames=Z0723, ECs0622;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Involved in the biosynthesis of the siderophore
CC       enterobactin (enterochelin), which is a macrocyclic trimeric
CC       lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone
CC       serves as a scaffolding for the three catechol functionalities
CC       that provide hexadentate coordination for the tightly ligated
CC       iron(2+) atoms. Plays an essential role in the assembly of the
CC       enterobactin by catalyzing the transfer of the 4'-
CC       phosphopantetheine (Ppant) moiety from coenzyme A to the apo-
CC       domains of both EntB (ArCP domain) and EntF (PCP domain) to yield
CC       their holo-forms which make them competent for the activation of
CC       2,3-dihydroxybenzoate (DHB) and L-serine, respectively.
CC       {ECO:0000250|UniProtKB:P19925}.
CC   -!- CATALYTIC ACTIVITY: CoA + apo-EntB/F = adenosine 3',5'-
CC       bisphosphate + holo-EntB/F. {ECO:0000250|UniProtKB:P19925}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000250|UniProtKB:P24224};
CC   -!- PATHWAY: Siderophore biosynthesis; enterobactin biosynthesis.
CC       {ECO:0000250|UniProtKB:P19925}.
CC   -!- SUBUNIT: EntB, EntD, EntE, and EntF form a multienzyme complex
CC       called enterobactin synthase. {ECO:0000250|UniProtKB:P19925}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P19925}.
CC   -!- SIMILARITY: Belongs to the P-Pant transferase superfamily. EntD
CC       family. {ECO:0000250|UniProtKB:P19925}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG54917.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
CC       Sequence=BAB34045.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
DR   EMBL; AE005174; AAG54917.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB34045.1; ALT_INIT; Genomic_DNA.
DR   PIR; A85557; A85557.
DR   PIR; F90706; F90706.
DR   RefSeq; NP_308649.2; NC_002695.1.
DR   RefSeq; WP_001506608.1; NZ_MWVM01000011.1.
DR   SMR; P0A3B9; -.
DR   STRING; 155864.Z0723; -.
DR   EnsemblBacteria; AAG54917; AAG54917; Z0723.
DR   EnsemblBacteria; BAB34045; BAB34045; BAB34045.
DR   GeneID; 916981; -.
DR   KEGG; ece:Z0723; -.
DR   KEGG; ecs:ECs0622; -.
DR   PATRIC; fig|386585.9.peg.730; -.
DR   eggNOG; ENOG4108TSE; Bacteria.
DR   eggNOG; COG2977; LUCA.
DR   HOGENOM; HOG000276815; -.
DR   KO; K02362; -.
DR   UniPathway; UPA00017; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0009366; C:enterobactin synthetase complex; ISS:UniProtKB.
DR   GO; GO:0031226; C:intrinsic component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0008897; F:holo-[acyl-carrier-protein] synthase activity; ISS:UniProtKB.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0009239; P:enterobactin biosynthetic process; ISS:UniProtKB.
DR   Gene3D; 3.90.470.20; -; 2.
DR   InterPro; IPR008278; 4-PPantetheinyl_Trfase_SF.
DR   InterPro; IPR003542; Enbac_synth_compD-like.
DR   Pfam; PF01648; ACPS; 1.
DR   PRINTS; PR01399; ENTSNTHTASED.
DR   SUPFAM; SSF56214; SSF56214; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0A3B9.
DR   SWISS-2DPAGE; P0A3B9.
KW   Complete proteome; Enterobactin biosynthesis; Magnesium; Membrane;
KW   Metal-binding; Transferase.
FT   CHAIN         1    206       Enterobactin synthase component D.
FT                                /FTId=PRO_0000206070.
FT   METAL       107    107       Magnesium. {ECO:0000250}.
FT   METAL       109    109       Magnesium. {ECO:0000250}.
FT   METAL       152    152       Magnesium. {ECO:0000250}.
SQ   SEQUENCE   206 AA;  23131 MW;  68005CD6E9C6AE0C CRC64;
     MKTTHTSLPF AGHTLHFVEF DPANFCEQDL LWLPHYAQLQ HAGRKRKTEH LAGRIAAVYA
     LREYGYKCVP AIGELRQPVW PAEVYGSISH CGATALAVVS RQPIGVDIEE IFSAQTATEL
     TDNIITPAEH ERLADCGLAF SLALTLAFSA KESAFKASEI QTDAGFLDYQ IISWNKQQVI
     IHRENEMFAV HWQIKEKIVI TLCQHD
//

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