(data stored in ACNUC7421 zone)

SWISSPROT: Q8XBV8_ECO57

ID   Q8XBV8_ECO57            Unreviewed;       377 AA.
AC   Q8XBV8; A0A0H3JDY6; Q7AGR9;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   08-MAY-2019, entry version 116.
DE   SubName: Full=Regulator of length of O-antigen component of lipopolysaccharide chains {ECO:0000313|EMBL:BAB34049.1};
GN   Name=fepE {ECO:0000313|EMBL:BAB34049.1};
GN   ORFNames=ECs_0626 {ECO:0000313|EMBL:BAB34049.1};
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334 {ECO:0000313|EMBL:BAB34049.1, ECO:0000313|Proteomes:UP000000558};
RN   [1] {ECO:0000313|EMBL:BAB34049.1, ECO:0000313|Proteomes:UP000000558}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 /
RC   EHEC {ECO:0000313|Proteomes:UP000000558};
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [2] {ECO:0000213|PDB:3B8M, ECO:0000213|PDB:3B8N}
RP   X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 64-331.
RX   PubMed=18204465; DOI=10.1038/nsmb.1374;
RA   Tocilj A., Munger C., Proteau A., Morona R., Purins L., Ajamian E.,
RA   Wagner J., Papadopoulos M., Van Den Bosch L., Rubinstein J.L.,
RA   Fethiere J., Matte A., Cygler M.;
RT   "Bacterial polysaccharide co-polymerases share a common framework for
RT   control of polymer length.";
RL   Nat. Struct. Mol. Biol. 15:130-138(2008).
RN   [3] {ECO:0000213|PDB:4E2L}
RP   X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 65-257 AND 262-328.
RX   PubMed=22437828; DOI=10.1074/jbc.M112.354837;
RA   Kalynych S., Yao D., Magee J., Cygler M.;
RT   "Structural characterization of closely related O-antigen
RT   lipopolysaccharide (LPS) chain length regulators.";
RL   J. Biol. Chem. 287:15696-15705(2012).
CC   -!- INTERACTION:
CC       Self; NbExp=4; IntAct=EBI-15680500, EBI-15680500;
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DR   EMBL; BA000007; BAB34049.1; -; Genomic_DNA.
DR   RefSeq; NP_308653.1; NC_002695.1.
DR   RefSeq; WP_000096698.1; NZ_SDVX01000001.1.
DR   PDB; 3B8M; X-ray; 2.70 A; A/B/C=64-331.
DR   PDB; 3B8N; X-ray; 3.10 A; A/B/C/D/E/F/G/H/I=65-331.
DR   PDB; 4E2L; X-ray; 2.80 A; A/B/C/D/E/F/G/H/I=65-257, A/B/C/D/E/F/G/H/I=265-331.
DR   PDBsum; 3B8M; -.
DR   PDBsum; 3B8N; -.
DR   PDBsum; 4E2L; -.
DR   SMR; Q8XBV8; -.
DR   DIP; DIP-46393N; -.
DR   STRING; 155864.EDL933_0657; -.
DR   EnsemblBacteria; AAG54922; AAG54922; Z0728.
DR   EnsemblBacteria; BAB34049; BAB34049; BAB34049.
DR   GeneID; 916985; -.
DR   KEGG; ecs:ECs0626; -.
DR   PATRIC; fig|386585.9.peg.736; -.
DR   eggNOG; ENOG4108QY5; Bacteria.
DR   eggNOG; COG3765; LUCA.
DR   BioCyc; ECOO157:FEPE-MONOMER; -.
DR   Proteomes; UP000000558; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR003856; LPS_length_determ_N_term.
DR   Pfam; PF02706; Wzz; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q8XBV8.
DR   SWISS-2DPAGE; Q8XBV8.
KW   3D-structure {ECO:0000213|PDB:3B8M, ECO:0000213|PDB:3B8N,
KW   ECO:0000213|PDB:4E2L};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000558};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000558}.
SQ   SEQUENCE   377 AA;  42135 MW;  DF86FEF538CFEB17 CRC64;
     MSSLNIKQGS DAHFPDYPLA SPSNNEIDLL NLISVLWRAK KTVMAVVFAF ACAGLLISFI
     LPQKWTSAAV VTPPEPVQWQ ELEKTFTKLR VLDLDIKIDR TEAFNLFIKK FQSVSLLEEY
     LRSSPYVMDQ LKEAKIDELD LHRAIVALSE KMKAVDDNAS KKKDEPSLYT SWTLSFTAPT
     SEEAQTVLSG YIDYISALVV KESIENVRNK LEIKTQFEKE KLAQDRIKMK NQLDANIQRL
     NYSLDIANAA GIKKPVYSNG QAVKDDPDFS ISLGADGIER KLEIEKAVTD VAELNGELRN
     RQYLVEQLTK ANINDVNFTP FKYQLSPSLP VKKDGPGKAI IVILSALIGG MVACGSVLLR
     YAMASRKQDA MMADHLV
//

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