(data stored in ACNUC7421 zone)

SWISSPROT: CITT_ECO57

ID   CITT_ECO57              Reviewed;         487 AA.
AC   P0AE75; P77405;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   05-JUL-2017, entry version 71.
DE   RecName: Full=Citrate/succinate antiporter;
DE   AltName: Full=Citrate carrier;
DE   AltName: Full=Citrate transporter;
GN   Name=citT; OrderedLocusNames=Z0756, ECs0651;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Responsible for the uptake of citrate in exchange to the
CC       efflux of succinate. Has a relatively broad specificity for C(4)-
CC       dicarboxylates and tricarboxylates (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47)
CC       family. DIT1 subfamily. {ECO:0000305}.
DR   EMBL; AE005174; AAG54947.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34074.1; -; Genomic_DNA.
DR   PIR; C90710; C90710.
DR   RefSeq; NP_308678.1; NC_002695.1.
DR   RefSeq; WP_000050323.1; NZ_MWVM01000011.1.
DR   ProteinModelPortal; P0AE75; -.
DR   STRING; 155864.Z0756; -.
DR   PRIDE; P0AE75; -.
DR   EnsemblBacteria; AAG54947; AAG54947; Z0756.
DR   EnsemblBacteria; BAB34074; BAB34074; BAB34074.
DR   GeneID; 917010; -.
DR   KEGG; ece:Z0756; -.
DR   KEGG; ecs:ECs0651; -.
DR   PATRIC; fig|386585.9.peg.762; -.
DR   eggNOG; ENOG4107QPK; Bacteria.
DR   eggNOG; COG0471; LUCA.
DR   HOGENOM; HOG000117911; -.
DR   KO; K09477; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   InterPro; IPR030676; CitT-rel.
DR   InterPro; IPR001898; SLC13A/DASS.
DR   PANTHER; PTHR42826; PTHR42826; 1.
DR   Pfam; PF00939; Na_sulph_symp; 1.
DR   PIRSF; PIRSF002457; DASS; 1.
DR   TIGRFAMs; TIGR00785; dass; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0AE75.
DR   SWISS-2DPAGE; P0AE75.
KW   Antiport; Cell inner membrane; Cell membrane; Complete proteome;
KW   Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    487       Citrate/succinate antiporter.
FT                                /FTId=PRO_0000172522.
FT   TRANSMEM     11     31       Helical. {ECO:0000255}.
FT   TRANSMEM     60     80       Helical. {ECO:0000255}.
FT   TRANSMEM     95    115       Helical. {ECO:0000255}.
FT   TRANSMEM    138    158       Helical. {ECO:0000255}.
FT   TRANSMEM    190    210       Helical. {ECO:0000255}.
FT   TRANSMEM    214    234       Helical. {ECO:0000255}.
FT   TRANSMEM    237    257       Helical. {ECO:0000255}.
FT   TRANSMEM    288    308       Helical. {ECO:0000255}.
FT   TRANSMEM    309    329       Helical. {ECO:0000255}.
FT   TRANSMEM    345    365       Helical. {ECO:0000255}.
FT   TRANSMEM    379    399       Helical. {ECO:0000255}.
FT   TRANSMEM    401    421       Helical. {ECO:0000255}.
FT   TRANSMEM    424    444       Helical. {ECO:0000255}.
FT   TRANSMEM    463    483       Helical. {ECO:0000255}.
SQ   SEQUENCE   487 AA;  53093 MW;  9AD55B9E7448F1DB CRC64;
     MSLAKDNIWK LLAPLVVMGV MFLIPVPDGM PPQAWHYFAV FVAMIVGMIL EPIPATAISF
     IAVTICVIGS NYLLFDAKEL ADPAFNAQKQ ALKWGLAGFS STTVWLVFGA FIFALGYEVS
     GLGRRIALFL VKFMGKRTLT LGYAIVIIDI LLAPFTPSNT ARTGGTVFPV IKNLPPLFKS
     FPNDPSARRI GGYLMWMMVI STSLSSSMFV TGAAPNVLGL EFVSKIAGIQ ISWLQWFLCF
     LPVGVILLII APWLSYVLYK PEITHSEEVA TWAGDELKTM GALTRREWTL IGLVLLSLGL
     WVFGSEVINA TAVGLLAVSL MLALHVVPWK DITRYNSAWN TLVNLATLVV MANGLTRSGF
     IDWFAGTMST HLEGFSPNAT VIVLVLVFYF AHYLFASLSA HTATMLPVIL AVGKGIPGVP
     MEQLCILLVL SIGIMGCLTP YATGPGVIIY GCGYVKSKDY WRLGAIFGVI YISMLLLVGW
     PILAMWN
//

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