(data stored in ACNUC7421 zone)

SWISSPROT: DPIA_ECO57

ID   DPIA_ECO57              Reviewed;         226 AA.
AC   P0AEF6; Q54149;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   30-AUG-2017, entry version 87.
DE   RecName: Full=Transcriptional regulatory protein DpiA;
DE   AltName: Full=Destabilizer of plasmid inheritance;
GN   Name=dpiA; Synonyms=citB; OrderedLocusNames=Z0765, ECs0659;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Member of the two-component regulatory system DpiA/DpiB,
CC       which is essential for expression of citrate-specific fermentation
CC       genes and genes involved in plasmid inheritance. Could be involved
CC       in response to both the presence of citrate and external redox
CC       conditions (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated and activated by DpiB. {ECO:0000250}.
DR   EMBL; AE005174; AAG54955.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34082.1; -; Genomic_DNA.
DR   PIR; C90711; C90711.
DR   PIR; G85561; G85561.
DR   RefSeq; NP_308686.1; NC_002695.1.
DR   RefSeq; WP_000126500.1; NZ_MWVM01000011.1.
DR   ProteinModelPortal; P0AEF6; -.
DR   SMR; P0AEF6; -.
DR   STRING; 155864.Z0765; -.
DR   PRIDE; P0AEF6; -.
DR   EnsemblBacteria; AAG54955; AAG54955; Z0765.
DR   EnsemblBacteria; BAB34082; BAB34082; BAB34082.
DR   GeneID; 917019; -.
DR   KEGG; ece:Z0765; -.
DR   KEGG; ecs:ECs0659; -.
DR   PATRIC; fig|386585.9.peg.770; -.
DR   eggNOG; ENOG4106YYS; Bacteria.
DR   eggNOG; COG4565; LUCA.
DR   HOGENOM; HOG000034816; -.
DR   KO; K07702; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001071; F:nucleic acid binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0009605; P:response to external stimulus; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   CDD; cd00156; REC; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR024187; Sig_transdc_resp-reg_cit/mal.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR028141; Transcriptional_reg_dom.
DR   Pfam; PF12431; CitT; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PIRSF; PIRSF006171; RR_citrat_malat; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0AEF6.
DR   SWISS-2DPAGE; P0AEF6.
KW   Activator; Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein;
KW   Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN         1    226       Transcriptional regulatory protein DpiA.
FT                                /FTId=PRO_0000081069.
FT   DOMAIN        6    122       Response regulatory.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00169}.
FT   DNA_BIND    180    199       H-T-H motif. {ECO:0000250}.
FT   MOD_RES      57     57       4-aspartylphosphate.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00169}.
SQ   SEQUENCE   226 AA;  25453 MW;  2A47279EED145743 CRC64;
     MTAPLTLLIV EDETPLAEMH AEYIRHIPGF SQILLAGNLA QARMMIERFK PGLILLDNYL
     PDGRGINLLH ELVQAHYPGD VVFTTAASDM ETVSEAVRCG VFDYLIKPIA YERLGQTLTR
     FRQRKHMLES IDSASQKQID EMFNAYARGE PKDELPTGID PLTLNAVRKL FKEPGVQHTA
     ETVAQALTIS RTTARRYLEY CASRHLIIAE IVHGKVGRPQ RIYHSG
//

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