(data stored in ACNUC7421 zone)

SWISSPROT: NAGC_ECO57

ID   NAGC_ECO57              Reviewed;         406 AA.
AC   P0AF22; P15301;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   05-JUL-2017, entry version 80.
DE   RecName: Full=N-acetylglucosamine repressor;
GN   Name=nagC; OrderedLocusNames=Z0823, ECs0706;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Acts as a repressor of the nagEBACD operon and acts both
CC       as an activator and a repressor for the transcription of the glmSU
CC       operon. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family. {ECO:0000305}.
DR   EMBL; AE005174; AAG54998.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34129.1; -; Genomic_DNA.
DR   PIR; B85567; B85567.
DR   PIR; B90717; B90717.
DR   RefSeq; NP_308733.1; NC_002695.1.
DR   RefSeq; WP_000187594.1; NZ_MWVM01000011.1.
DR   ProteinModelPortal; P0AF22; -.
DR   SMR; P0AF22; -.
DR   STRING; 155864.Z0823; -.
DR   PRIDE; P0AF22; -.
DR   EnsemblBacteria; AAG54998; AAG54998; Z0823.
DR   EnsemblBacteria; BAB34129; BAB34129; BAB34129.
DR   GeneID; 917075; -.
DR   KEGG; ece:Z0823; -.
DR   KEGG; ecs:ECs0706; -.
DR   PATRIC; fig|386585.9.peg.818; -.
DR   eggNOG; ENOG4105E2R; Bacteria.
DR   eggNOG; COG1940; LUCA.
DR   HOGENOM; HOG000275182; -.
DR   KO; K02565; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR000600; ROK.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   PANTHER; PTHR18964; PTHR18964; 1.
DR   Pfam; PF01047; MarR; 1.
DR   Pfam; PF00480; ROK; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS01125; ROK; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0AF22.
DR   SWISS-2DPAGE; P0AF22.
KW   Activator; Carbohydrate metabolism; Complete proteome; DNA-binding;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN         1    406       N-acetylglucosamine repressor.
FT                                /FTId=PRO_0000095692.
FT   DNA_BIND     35     44       H-T-H motif. {ECO:0000250}.
SQ   SEQUENCE   406 AA;  44541 MW;  28C4C85D736627C8 CRC64;
     MTPGGQAQIG NVDLVKQLNS AAVYRLIDQY GPISRIQIAE QSQLAPASVT KITRQLIERG
     LIKEVDQQAS TGGRRAISIV TETRNFHAIG VRLGRHDATI TLFDLSSKVL AEEHYPLPER
     TQQTLEHALL NAIAQFIDSY QRKLRELIAI SVILPGLVDP DSGKIHYMPH IQVENWGLVE
     ALEERFKVTC FVGHDIRSLA LAEHYFGASQ DCEDSILVRV HRGTGAGIIS NGRIFIGRNG
     NVGEIGHIQV EPLGERCHCG NFGCLETIAA NAAIEQRVLN LLKQGYQSRV PLDDCTIKTI
     CKAANKGDSL ASEVIEYVGR HLGKTIAIAI NLFNPQKIVI AGEITEADKV LLPAIESCIN
     TQALKAFRTN LPVVRSELDH RSAIGAFALV KRAMLNGILL QHLLEN
//

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