(data stored in ACNUC7421 zone)

SWISSPROT: FUR_ECO57

ID   FUR_ECO57               Reviewed;         148 AA.
AC   P0A9B1; P06975;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   05-JUL-2017, entry version 82.
DE   RecName: Full=Ferric uptake regulation protein;
DE            Short=Ferric uptake regulator;
GN   Name=fur; OrderedLocusNames=Z0831, ECs0714;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
RA   Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
RA   Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
RA   Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
RA   Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
RA   Welch R.A., Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
RA   Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
RA   Kuhara S., Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli
RT   O157:H7 and genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Acts as a global negative controlling element, employing
CC       Fe(2+) as a cofactor to bind the operator of the repressed genes.
CC       Regulates the expression of several outer-membrane proteins
CC       including the iron transport operon (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Fur family. {ECO:0000305}.
DR   EMBL; AE005174; AAG55006.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34137.1; -; Genomic_DNA.
DR   PIR; B85568; B85568.
DR   PIR; B90718; B90718.
DR   RefSeq; NP_308741.1; NC_002695.1.
DR   RefSeq; WP_000131702.1; NZ_MWVM01000011.1.
DR   ProteinModelPortal; P0A9B1; -.
DR   SMR; P0A9B1; -.
DR   STRING; 155864.Z0831; -.
DR   PRIDE; P0A9B1; -.
DR   EnsemblBacteria; AAG55006; AAG55006; Z0831.
DR   EnsemblBacteria; BAB34137; BAB34137; BAB34137.
DR   GeneID; 917083; -.
DR   KEGG; ece:Z0831; -.
DR   KEGG; ecs:ECs0714; -.
DR   PATRIC; fig|386585.9.peg.830; -.
DR   eggNOG; ENOG41090R7; Bacteria.
DR   eggNOG; COG0735; LUCA.
DR   HOGENOM; HOG000014144; -.
DR   KO; K03711; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   CDD; cd07153; Fur_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR002481; FUR.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF01475; FUR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
DR   PRODOM; P0A9B1.
DR   SWISS-2DPAGE; P0A9B1.
KW   Complete proteome; Cytoplasm; DNA-binding; Iron; Metal-binding;
KW   Repressor; Transcription; Transcription regulation; Zinc.
FT   CHAIN         1    148       Ferric uptake regulation protein.
FT                                /FTId=PRO_0000095551.
FT   REGION        1     84       DNA-binding. {ECO:0000250}.
FT   REGION       85    148       Dimerization. {ECO:0000250}.
FT   COMPBIAS     86     90       His-rich.
FT   METAL        33     33       Zinc. {ECO:0000250}.
FT   METAL        81     81       Zinc. {ECO:0000250}.
FT   METAL        87     87       Iron. {ECO:0000250}.
FT   METAL        89     89       Iron. {ECO:0000250}.
FT   METAL        90     90       Zinc. {ECO:0000250}.
FT   METAL        93     93       Zinc. {ECO:0000250}.
FT   METAL        96     96       Zinc. {ECO:0000250}.
FT   METAL       101    101       Zinc. {ECO:0000250}.
FT   METAL       108    108       Iron. {ECO:0000250}.
FT   METAL       125    125       Iron. {ECO:0000250}.
SQ   SEQUENCE   148 AA;  16795 MW;  B868360513489DD3 CRC64;
     MTDNNTALKK AGLKVTLPRL KILEVLQEPD NHHVSAEDLY KRLIDMGEEI GLATVYRVLN
     QFDDAGIVTR HNFEGGKSVF ELTQQHHHDH LICLDCGKVI EFSDDSIEAR QREIAAKHGI
     RLTNHSLYLY GHCAEGDCRE DEHAHEGK
//

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