(data stored in ACNUC7421 zone)

SWISSPROT: TRPC_RHILO

ID   TRPC_RHILO              Reviewed;         270 AA.
AC   Q98ME3;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   11-DEC-2019, entry version 93.
DE   RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000255|HAMAP-Rule:MF_00134};
DE            Short=IGPS {ECO:0000255|HAMAP-Rule:MF_00134};
DE            EC=4.1.1.48 {ECO:0000255|HAMAP-Rule:MF_00134};
GN   Name=trpC {ECO:0000255|HAMAP-Rule:MF_00134}; OrderedLocusNames=mlr0615;
OS   Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)
OS   (Mesorhizobium loti (strain MAFF 303099)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=266835;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 29417 / CECT 9101 / MAFF 303099;
RX   PubMed=11214968; DOI=10.1093/dnares/7.6.331;
RA   Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y.,
RA   Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y.,
RA   Nakayama S., Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M.,
RA   Tabata S.;
RT   "Complete genome structure of the nitrogen-fixing symbiotic bacterium
RT   Mesorhizobium loti.";
RL   DNA Res. 7:331-338(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00134};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5. {ECO:0000255|HAMAP-
CC       Rule:MF_00134}.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00134}.
DR   EMBL; BA000012; BAB48170.1; -; Genomic_DNA.
DR   RefSeq; WP_010909525.1; NC_002678.2.
DR   SMR; Q98ME3; -.
DR   STRING; 266835.14021558; -.
DR   PRIDE; Q98ME3; -.
DR   EnsemblBacteria; BAB48170; BAB48170; BAB48170.
DR   KEGG; mlo:mlr0615; -.
DR   PATRIC; fig|266835.9.peg.492; -.
DR   eggNOG; ENOG4105DK0; Bacteria.
DR   eggNOG; COG0134; LUCA.
DR   HOGENOM; HOG000230463; -.
DR   KO; K01609; -.
DR   OMA; RKDFMVD; -.
DR   OrthoDB; 1789381at2; -.
DR   BioCyc; MLOT266835:G1G20-506-MONOMER; -.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000000552; Chromosome.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_B; IGPS_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q98ME3.
DR   SWISS-2DPAGE; Q98ME3.
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Decarboxylase;
KW   Lyase; Tryptophan biosynthesis.
FT   CHAIN           1..270
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /id="PRO_0000154244"
SQ   SEQUENCE   270 AA;  29284 MW;  CE4DAF267EB1B78B CRC64;
     MSDILRKIEA YKRDEIAAAK AHVPLAEIKA RAKDADAPRG FLAALEAKRR SGRFALIAEI
     KKASPSKGLI RADFDPPALA QAYEKGGAAC LSVLTDAPSF QGAPEFLTKA RAAVALPALR
     KDFLFDPYQV YEARAWGADA ILIIMASVDD ALASALEATA FELGMDALIE VHDEAETQRA
     LKLSSRLIGI NNRNLRTFET SLETSERLAT MVPADRLLVS ESGIFTHDDC LRLQKKDIGT
     FLVGESLMRQ EDVTAATRIL LTGKALAEVV
//

If you have problems or comments...

PBIL Back to PBIL home page