(data stored in ACNUC1829 zone)

SWISSPROT: TSN18_HUMAN

ID   TSN18_HUMAN             Reviewed;         248 AA.
AC   Q96SJ8; Q6UY44; Q8NBI9;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   08-MAY-2019, entry version 126.
DE   RecName: Full=Tetraspanin-18;
DE            Short=Tspan-18;
GN   Name=TSPAN18; ORFNames=UNQ3042/PRO9858;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-133.
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC11690.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; AK027715; BAB55318.1; -; mRNA.
DR   EMBL; AK075547; BAC11690.1; ALT_INIT; mRNA.
DR   EMBL; AY358087; AAQ88454.1; -; mRNA.
DR   CCDS; CCDS7910.1; -.
DR   RefSeq; NP_570139.3; NM_130783.4.
DR   RefSeq; XP_006718436.1; XM_006718373.3.
DR   RefSeq; XP_011518761.1; XM_011520459.2.
DR   BioGrid; 124669; 2.
DR   IntAct; Q96SJ8; 1.
DR   STRING; 9606.ENSP00000339820; -.
DR   TCDB; 8.A.40.1.23; the tetraspanin (tetraspanin) family.
DR   SwissPalm; Q96SJ8; -.
DR   BioMuta; TSPAN18; -.
DR   DMDM; 68053316; -.
DR   EPD; Q96SJ8; -.
DR   jPOST; Q96SJ8; -.
DR   PaxDb; Q96SJ8; -.
DR   PeptideAtlas; Q96SJ8; -.
DR   PRIDE; Q96SJ8; -.
DR   ProteomicsDB; 78117; -.
DR   DNASU; 90139; -.
DR   Ensembl; ENST00000340160; ENSP00000339820; ENSG00000157570.
DR   Ensembl; ENST00000520358; ENSP00000429993; ENSG00000157570.
DR   GeneID; 90139; -.
DR   KEGG; hsa:90139; -.
DR   UCSC; uc001mye.5; human.
DR   CTD; 90139; -.
DR   DisGeNET; 90139; -.
DR   GeneCards; TSPAN18; -.
DR   H-InvDB; HIX0036374; -.
DR   HGNC; HGNC:20660; TSPAN18.
DR   neXtProt; NX_Q96SJ8; -.
DR   OpenTargets; ENSG00000157570; -.
DR   PharmGKB; PA142670688; -.
DR   eggNOG; KOG3882; Eukaryota.
DR   eggNOG; ENOG4111IRY; LUCA.
DR   GeneTree; ENSGT00940000157667; -.
DR   HOGENOM; HOG000230651; -.
DR   InParanoid; Q96SJ8; -.
DR   KO; K17353; -.
DR   OrthoDB; 1232467at2759; -.
DR   PhylomeDB; Q96SJ8; -.
DR   TreeFam; TF352892; -.
DR   ChiTaRS; TSPAN18; human.
DR   GenomeRNAi; 90139; -.
DR   PRO; PR:Q96SJ8; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000157570; Expressed in 155 organ(s), highest expression level in cardiac muscle of right atrium.
DR   ExpressionAtlas; Q96SJ8; baseline and differential.
DR   Genevisible; Q96SJ8; HS.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR000301; Tetraspanin.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q96SJ8.
DR   SWISS-2DPAGE; Q96SJ8.
KW   Complete proteome; Glycoprotein; Membrane; Polymorphism;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN         1    248       Tetraspanin-18.
FT                                /FTId=PRO_0000219268.
FT   TOPO_DOM      1     13       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     14     34       Helical. {ECO:0000255}.
FT   TOPO_DOM     35     49       Extracellular. {ECO:0000255}.
FT   TRANSMEM     50     70       Helical. {ECO:0000255}.
FT   TOPO_DOM     71     83       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     84    104       Helical. {ECO:0000255}.
FT   TOPO_DOM    105    223       Extracellular. {ECO:0000255}.
FT   TRANSMEM    224    244       Helical. {ECO:0000255}.
FT   TOPO_DOM    245    248       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD    111    111       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    129    129       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   VARIANT     133    133       V -> I (in dbSNP:rs2291334).
FT                                {ECO:0000269|PubMed:12975309}.
FT                                /FTId=VAR_057279.
SQ   SEQUENCE   248 AA;  27710 MW;  6E2869E9D1D35C8E CRC64;
     MEGDCLSCMK YLMFVFNFFI FLGGACLLAI GIWVMVDPTG FREIVAANPL LLTGAYILLA
     MGGLLFLLGF LGCCGAVREN KCLLLFFFLF ILIIFLAELS AAILAFIFRE NLTREFFTKE
     LTKHYQGNND TDVFSATWNS VMITFGCCGV NGPEDFKFAS VFRLLTLDSE EVPEACCRRE
     PQSRDGVLLS REECLLGRSL FLNKQGCYTV ILNTFETYVY LAGALAIGVL AIELFAMIFA
     MCLFRGIQ
//

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